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Open Access Highly Accessed Review

Effect of garlic on cardiovascular disorders: a review

Sanjay K Banerjee and Subir K Maulik*

Author Affiliations

Departments of Pharmacology, All India Institute of Medical sciences, New Delhi – 110029, India

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Nutrition Journal 2002, 1:4  doi:10.1186/1475-2891-1-4

Published: 19 November 2002

Abstract

Garlic and its preparations have been widely recognized as agents for prevention and treatment of cardiovascular and other metabolic diseases, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes. Effectiveness of garlic in cardiovascular diseases was more encouraging in experimental studies, which prompted several clinical trials. Though many clinical trials showed a positive effect of garlic on almost all cardiovascular conditions mentioned above, however a number of negative studies have recently cast doubt on the efficary of garlic specially its cholesterol lowering effect of garlic. It is a great challenge for scientists all over the world to make a proper use of garlic and enjoy its maximum beneficial effect as it is the cheapest way to prevent cardiovascular disease. This review has attempted to make a bridge the gap between experimental and clinical study and to discuss the possible mechanisms of such therapeutic actions of garlic.

Keywords:
garlic; animal experiment; clinical trial; cardiovascular