Table 1

Summary of measures assessed over the study duration.

Outcome measures and covariates

Time points (months)

~ -3

0

6

12

18

MMSE

x

x

x

Cognitive measures

x

x

x

x

Physical activity, functional capacity, and well-being measures

x

x

x

x

Height

x

Blood pressure, weight

x

x

x

x

Erythrocyte membrane n-3 and n-6 fatty acid status

x

x

x

x

Serum folate and Vitamin B12, and plasma carotenoid levels

x

x

Lipids, glucose, glycated haemoglobin, homocysteine

x

x

Medications, supplement use, adverse events and health changes

x

x

x

x

ApoE genotype

x

Inflammation (CRP), oxidative stress (MDA), and telomere length

x

x

Dietary data - general FFQ

x

x

Dietary data - n-3 consumption FFQ

x

x

x

x

Dietary data - historical seafood consumption FFQ

x

Abbreviations: MMSE = Mini-mental state examination; n-3 = omega-3; n-6 = omega-6; FFQ = food frequency questionnaire; ApoE = Apolipoprotein E.

Danthiir et al. Nutrition Journal 2011 10:117   doi:10.1186/1475-2891-10-117