Oxidative stress marker response to three high fat meals differing in fat type. Over 4 h, a) the area under the curve for peripheral blood mononuclear cell nuclear factor-κB (NF-κB) activation was higher for O3FA than SFA (p < 0.05) as determined by densitometric data analysis following EMSA analysis and b) shown in a representative EMSA image of NF-κB activation. Also, c) plasma 8-epi prostaglandinF2α (8-epi) analyzed by GC/MS decreased over time with no difference between groups (p < 0.02) and d) no difference in area under the curve. Data are presented as Mean ± SEM. O3FA = omega 3 fatty acid enriched meal, SFA = high saturated fat meal, and MFA = high monounsaturated fat meal. * indicates time point difference from baseline. a, b Difference in superscript denotes difference between meals as the area under the curve for O3FA > SFA (p<0.05)..
Peairs et al. Nutrition Journal 2011 10:122 doi:10.1186/1475-2891-10-122