Email updates

Keep up to date with the latest news and content from Nutrition Journal and BioMed Central.

Open Access Short report

Relationship of Adiposity and Insulin Resistance Mediated by Inflammation in a Group of Overweight and Obese Chilean Adolescents

Marcela Reyes1*, Sheila Gahagan23, Erik Díaz1, Estela Blanco2, Laura Leiva1, Lydia Lera1 and Raquel Burrows1

Author Affiliations

1 Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile

2 Division of Child Development and Community Health, Department of Pediatrics, University of California, San Diego, USA

3 Center for Human Growth and Development, University of Michigan, Ann Arbor, USA

For all author emails, please log on.

Nutrition Journal 2011, 10:4  doi:10.1186/1475-2891-10-4

Published: 14 January 2011


The mild chronic inflammatory state associated with obesity may be an important link between adiposity and insulin resistance (IR). In a sample of 137 overweight and obese Chilean adolescents, we assessed associations between high-sensitivity C-reactive protein (hs-CRP), IR and adiposity; explored sex differences; and evaluated whether hs-CRP mediated the relationship between adiposity and IR. Positive relationships between hs-CRP, IR and 2 measures of adiposity were found. Hs-CRP was associated with waist circumference (WC) in boys and fat mass index (FMI) in girls. Using path analysis, we found that hs-CRP mediated the relationship between adiposity (WC and FMI) and the homeostatic model assessment of insulin resistance (HOMA-IR) (p < 0.05) in both sexes. Our novel finding is that inflammation statistically mediated the well described link between increased adiposity and IR.