Figure 5.

OMC inhibits ConA-induced splenocyte proliferation and production of IFN-γ, IL-6 and IL-4. Splenocytes were cultured in the presence of ConA (5 μg/ml) and OMC (0-100 μg/ml) for 72 hours. (A) cell proliferation, (B) production of IFN-γ, (C) IL-2, and (D) IL-4 was determined as described in Materials and Methods. The data are means ± S.D. of triplicate measurements. Similar data were obtained in two additional independent experiments. Means without a common letter differ, P < 0.05.