Table 3

Effects of longitudinal changes of nutritional parameters on changes (slopes) of leptin during 24 months based on mixed-effects model with linear trends for variable and fixed parameters

95% confidence interval

Estimate

Lower

Upper

F

P


DEI (kcal/kg/d)

-0.0154

-0.3756

0.3448

0.007

0.93

Albumin (g/L)

0.0369

-0.7011

0.7750

0.010

0.92

IL-6 (mcg/ml)

0.0534

-0.0397

0.1465

1.289

0.26

EPO dose (x102u/kg/w)

-0.0001

-0.0176

0.0173

0.0001

0.99

FMI (kg/m2)

5.4558

4.4808

6.4308

121.918

< 0.001

Age (years)

-0.2072

-0.5850

0.1706

1.187

0.28

Gender (men v women)

-11.7523

-21.2601

-2.2445

6.018

0.016

DM (yes v no)

-0.7272

-9.2410

7.7867

0.029

0.87

History of CV disease (yes v no)

-0.9497

-9.6537

7.7544

0.047

0.83

Dialysis vintage (months)

0.0341

-0.0849

0.1531

0.325

0.57

Time (months)

-2.5010

-3.5814

-1.4205

21.650

< 0.001


NOTE: The Table represents a simple Mixed-Model with leptin as dependent variable, and presented nutritional parameters and fixed factors (age, gender, DM status, dialysis vintage and history of CV disease) as independent variables. The model takes into account every measurements of leptin and presented nutritional variables in each time point for each patient separately.

Abbreviations: DEI, daily energy intake; IL-6, interleukin-6; EPO, erythropoietin; FMI, fat mass index; DM, diabetes mellitus; CV, cardio-vascular.

Beberashvili et al. Nutrition Journal 2011 10:68   doi:10.1186/1475-2891-10-68

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