Table 3 |
||||||
|
Anthropometric and laboratory parameters at baseline and 12 weeks, by group |
||||||
|
RSV+Fib |
RSV |
SIM/EZE+Fib |
SIM+EZE |
P-value1 |
P-value2 |
|
|
N = 28 |
N = 30 |
N = 28 |
n = 30 |
|||
|
|
||||||
|
Weight kg |
||||||
|
Baseline |
74 (3) |
72 (2) |
73 (3) |
70 (2) |
0.001 |
0.803 |
|
12 weeks |
73 (3) |
72 (3) |
72 (3) |
70 (2) |
||
|
BMI kg/m2 |
||||||
|
Baseline |
28 (1) |
30 (1) |
30 (1) |
28 (1) |
0.005 |
0.246 |
|
12 weeks |
27 (1) |
30 (1) |
29 (1) |
28 (1) |
||
|
Glucose mg/dL |
||||||
|
Baseline |
97 (2) |
104 (4) |
103 (5) |
108 (7) |
0.754 |
0.257 |
|
12 weeks |
95 (2) |
104 (4) |
100 (4) |
109 (6) |
||
|
HbA1c % |
||||||
|
Baseline |
5.7 (0.1) |
6.3 (0.2) |
6.0 (0.2) |
6.2 (0.2) |
0.02 |
0.215 |
|
12 weeks |
5.8 (0.1) |
6.2 (0.2) |
6.1 (0.2) |
6.3 (0.2) |
||
|
hsCRP mg/L |
||||||
|
Baseline |
4.2 (1.1) |
3.7 (0.5) |
3.3 (0.4) |
4.5 (1.3) |
<0.001 |
0.976 |
|
12 weeks |
2.4 (0.5) |
2.5 (0.4) |
2.3 (0.4) |
2.3 (0.4) |
||
|
Cholesterol mg/dL |
||||||
|
Baseline |
256 (10) |
244 (8) |
247 (8) |
241 (9) |
<0.0001 |
0.639 |
|
12 weeks |
149 (6) |
140 (5) |
155 (9) |
147 (8) |
||
|
LDL-C mg/dL |
||||||
|
Baseline |
167 (8) |
154 (7) |
162 (6) |
158 (8) |
<0.001 |
0.436 |
|
12 weeks |
70 (5) |
64 (4) |
80 (8) |
72 (4) |
||
|
HDL-C mg/dL |
||||||
|
Baseline |
57 (3) |
52 (2) |
52 (2) |
54 (2) |
0.392 |
0.351 |
|
12 weeks |
57 (3) |
50 (3) |
53 (3) |
52 (2) |
||
|
Triglycerides mg/dL |
||||||
|
Baseline |
160 (13) |
187 (16) |
158 (14) |
144 (10) |
<0.001 |
0.291 |
|
12 weeks |
110 (9) |
123 (8) |
110 (7) |
108 (9) |
||
|
Apoliprotein A1 mg/dL |
||||||
|
Baseline |
153 (6) |
145 (6) |
141 (4) |
147 (3) |
0.035 |
0.482 |
|
12 weeks |
155 (6) |
149 (6) |
145 (5) |
152 (4) |
||
|
Apoliprotein B mg/dL |
||||||
|
Baseline |
133 (6) |
133 (5) |
133 (5) |
134 (6) |
<0.001 |
0.775 |
|
12 weeks |
68 (3) |
67 (3) |
73 (5) |
70 (4) |
||
|
Campesterol mg/dL |
||||||
|
Baseline |
1.2 (0.2) |
1.1 (0.1) |
0.9 (0.1) |
1.3 (0.2) |
<0.001 |
0.005 |
|
12 weeks |
0.9 (0.1) |
1.0 (0.1) |
0.5 (0.1) |
0.8 (0.1) |
||
|
β-sitosterol mg/dL |
||||||
|
Baseline |
0.7 (0.1) |
0.8 (0.1) |
0.6 (0.1) |
0.9 (0.1) |
0.03 |
0.072 |
|
12 weeks |
0.6 (0.6) |
0.7 (0.1) |
0.5 (0.1) |
0.6 (0.1) |
||
|
Desmosterol mg/dL |
||||||
|
Baseline |
0.7 (0.1) |
1.9 (1.6) |
0.9 (0.3) |
0.5 (0.1) |
0.005 |
0.373 |
|
12 weeks |
0.6 (0.1) |
0.9 (0.5) |
1.0 (0.3) |
1.6 (0.5) |
||
|
|
||||||
|
Differences analyzed by General Linear Model-repeated measures, followed by Tukey's test. HbA1c = glycated hemoglobin; hs-CRP = highly-sensitive C-reactive protein; RSV = rosuvastatin 40 mg; Fib = fiber; SIM = simvastatin 40 mg; EZE = ezetimibe 10 mg. 1Differences between baseline and 12 week; 2Differences between groups. |
||||||
|
Ramos et al. Nutrition Journal 2011 10:80 doi:10.1186/1475-2891-10-80 |
||||||
