Table 3

Anthropometric and laboratory parameters at baseline and 12 weeks, by group

RSV+Fib

RSV

SIM/EZE+Fib

SIM+EZE

P-value1

P-value2

N = 28

N = 30

N = 28

n = 30


Weight kg

Baseline

74 (3)

72 (2)

73 (3)

70 (2)

0.001

0.803

12 weeks

73 (3)

72 (3)

72 (3)

70 (2)

BMI kg/m2

Baseline

28 (1)

30 (1)

30 (1)

28 (1)

0.005

0.246

12 weeks

27 (1)

30 (1)

29 (1)

28 (1)

Glucose mg/dL

Baseline

97 (2)

104 (4)

103 (5)

108 (7)

0.754

0.257

12 weeks

95 (2)

104 (4)

100 (4)

109 (6)

HbA1c %

Baseline

5.7 (0.1)

6.3 (0.2)

6.0 (0.2)

6.2 (0.2)

0.02

0.215

12 weeks

5.8 (0.1)

6.2 (0.2)

6.1 (0.2)

6.3 (0.2)

hsCRP mg/L

Baseline

4.2 (1.1)

3.7 (0.5)

3.3 (0.4)

4.5 (1.3)

<0.001

0.976

12 weeks

2.4 (0.5)

2.5 (0.4)

2.3 (0.4)

2.3 (0.4)

Cholesterol mg/dL

Baseline

256 (10)

244 (8)

247 (8)

241 (9)

<0.0001

0.639

12 weeks

149 (6)

140 (5)

155 (9)

147 (8)

LDL-C mg/dL

Baseline

167 (8)

154 (7)

162 (6)

158 (8)

<0.001

0.436

12 weeks

70 (5)

64 (4)

80 (8)

72 (4)

HDL-C mg/dL

Baseline

57 (3)

52 (2)

52 (2)

54 (2)

0.392

0.351

12 weeks

57 (3)

50 (3)

53 (3)

52 (2)

Triglycerides mg/dL

Baseline

160 (13)

187 (16)

158 (14)

144 (10)

<0.001

0.291

12 weeks

110 (9)

123 (8)

110 (7)

108 (9)

Apoliprotein A1 mg/dL

Baseline

153 (6)

145 (6)

141 (4)

147 (3)

0.035

0.482

12 weeks

155 (6)

149 (6)

145 (5)

152 (4)

Apoliprotein B mg/dL

Baseline

133 (6)

133 (5)

133 (5)

134 (6)

<0.001

0.775

12 weeks

68 (3)

67 (3)

73 (5)

70 (4)

Campesterol mg/dL

Baseline

1.2 (0.2)

1.1 (0.1)

0.9 (0.1)

1.3 (0.2)

<0.001

0.005

12 weeks

0.9 (0.1)

1.0 (0.1)

0.5 (0.1)

0.8 (0.1)

β-sitosterol mg/dL

Baseline

0.7 (0.1)

0.8 (0.1)

0.6 (0.1)

0.9 (0.1)

0.03

0.072

12 weeks

0.6 (0.6)

0.7 (0.1)

0.5 (0.1)

0.6 (0.1)

Desmosterol mg/dL

Baseline

0.7 (0.1)

1.9 (1.6)

0.9 (0.3)

0.5 (0.1)

0.005

0.373

12 weeks

0.6 (0.1)

0.9 (0.5)

1.0 (0.3)

1.6 (0.5)


Differences analyzed by General Linear Model-repeated measures, followed by Tukey's test. HbA1c = glycated hemoglobin; hs-CRP = highly-sensitive C-reactive protein; RSV = rosuvastatin 40 mg; Fib = fiber; SIM = simvastatin 40 mg; EZE = ezetimibe 10 mg. 1Differences between baseline and 12 week; 2Differences between groups.

Ramos et al. Nutrition Journal 2011 10:80   doi:10.1186/1475-2891-10-80

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