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Open Access Highly Accessed Research

Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial

Nicole M Wedick1*, Aoife M Brennan2, Qi Sun14, Frank B Hu134, Christos S Mantzoros256 and Rob M van Dam134

Author affiliations

1 Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

2 Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

3 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

4 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA

5 Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA

6 Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA

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Citation and License

Nutrition Journal 2011, 10:93  doi:10.1186/1475-2891-10-93

Published: 13 September 2011

Abstract

Background

Coffee consumption has been associated with a lower risk of type 2 diabetes in prospective cohort studies, but the underlying mechanisms remain unclear. The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes.

Methods

Randomized parallel-arm intervention conducted in 45 healthy overweight volunteers who were nonsmokers and regular coffee consumers. Participants were assigned to consumption of 5 cups (177 mL each) per day of instant caffeinated coffee, decaffeinated coffee, or no coffee (i.e., water) for 8 weeks.

Results

Average age was 40 years and body mass index was 29.5 kg/m2. Compared with consuming no coffee, consumption of caffeinated coffee increased adiponectin (difference in change from baseline 1.4 μg/mL; 95% CI: 0.2, 2.7) and interleukin-6 (difference: 60%; 95% CI: 8, 138) concentrations and consumption of decaffeinated coffee decreased fetuin-A concentrations (difference: -20%; 95% CI: -35, -1). For measures of glucose tolerance, insulin sensitivity, and insulin secretion, no significant differences were found between treatment groups.

Conclusions

Although no changes in glycemia and/or insulin sensitivity were observed after 8 weeks of coffee consumption, improvements in adipocyte and liver function as indicated by changes in adiponectin and fetuin-A concentrations may contribute to beneficial metabolic effects of long-term coffee consumption.

Trial Registration

clinicaltrials.gov NCT00305097