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Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial

Nicole M Wedick1*, Aoife M Brennan2, Qi Sun14, Frank B Hu134, Christos S Mantzoros256 and Rob M van Dam134

Author Affiliations

1 Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

2 Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

3 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

4 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA

5 Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA

6 Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA

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Nutrition Journal 2011, 10:93  doi:10.1186/1475-2891-10-93

Published: 13 September 2011

Additional files

Additional file 1:

Additional figures and table entitled Figure S1, Figure S2, Figure S3 and Table S1. Figure S1. Flow of participants through the study.; Figure S2. Compliance at 6-week visit determined from non-fasting serum caffeine concentrations. Shown are mean ± standard error values for caffeine and metabolites concentrations. Regular coffee (n = 14), Decaffeinated coffee (n = 13), No coffee (n = 14).; Figure S3. Association between change in adiponectin concentrations and change in 2-hour glucose concentrations during the study. Shown is a scatterplot of participant values for change from baseline at Week 8 in 2-hour glucose versus change in adiponectin including the simple linear regression line.; and Table S1. Body composition, lifestyle, and diet by coffee treatment group at baseline and the end of the trial.

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