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Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study

Siaw C Liew1*, Esha Das-Gupta2, Shew F Wong1, Nagarajah Lee3, Najeeb Safdar4 and Adawiyah Jamil5

Author affiliations

1 Department of Postgraduate Studies and Research, International Medical University, Kuala Lumpur, Malaysia

2 Department of Internal Medicine, International Medical University, Seremban, Malaysia

3 Open University, Kuala Lumpur, Malaysia

4 Department of Dermatology, Tuanku Ja'afar Hospital, Seremban, Malaysia

5 Department of Dermatology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia

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Citation and License

Nutrition Journal 2012, 11:1  doi:10.1186/1475-2891-11-1

Published: 5 January 2012



The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels.


This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fasting blood samples were collected from a subgroup of consented psoriasis vulgaris patients and matched controls (n = 84) for the quantification of homocysteine, vitamin B12 and folic acid levels.


There was no significant increase of the MTHFR 677 C > T mutation in patients with psoriasis vulgaris compared with controls (χ2 = 0.733, p = 0.392). No significant association between homocysteine levels and MTHFR gene polymorphism in cases and controls were observed (F = 0.91, df = 3, 80, p = 0.44). However, homocysteine levels in cases were negatively correlated with vitamin B12 (r = -0.173) and folic acid (r = -0.345) levels. Vitamin B12 and folic acid levels in cases were also negatively correlated (r = -0.164).


Our results indicate that there was no significant association between the MTHFR gene polymorphism and psoriasis vulgaris in the Malaysian population. There was no significant increase of the plasma homocysteine level in the psoriasis patients compared to the controls.