Table 1

Changes in [25(OH)D] following a single dose of 70,000 IU vitamin D3 in non-pregnant and pregnant women in Dhaka, Bangladesha
All participants Non-pregnant Pregnant Pb
N (all participants) 61 34 27
Baseline [25(OH)D] (N=61)
Mean [95% CI] 47 [42, 52] 54 [47, 62] 39 [34, 45] 0.010
Range 21, 96 27, 96 21, 95
Δ[25(OH)D], Mean [95% CI], nmol/L
Day 2 (N=27) 20 [15,25] 24 [17, 33] 15 [11,22] 0.037
Day 4 (N=27) 23 [18, 30] 24 [17, 34] 23 [16, 32] 0.800
Day 7 (N=29) 26 [21, 33] 25 [18, 34] 28 [20, 40] 0.134
Day 21 (N=14) 25 [18, 35] 21 [14, 33] 32 [20, 51] 0.003
Day 56 (N=12) 16 [11,23] 14 [9,21] 20 [12, 33] 0.101
Participants in single-dose only groups
N (% followed more than 7 days) 31 (51%) 18 (53%) 13 (48%)
# Specimens per participant
Median 6 6 6
Range 3, 6 3, 6 3, 6
Baseline [25(OH)D] (N=31)
Mean [95% CI] 48 [41, 56] 52 [42, 64] 43 [34, 55] 0.224
Range 21, 96 27, 96 21, 95
Tmax, days (N=31)
Mean [95% CI] 11 [7,18] 9 [4,17] 17 [10,29] 0.134
Range 2, 70 2, 70 2, 70
Cmax, nmol/L (N=31)
Mean [95% CI] 85 [77, 93] 87 [75, 101] 82 [72, 92] 0.500
Range 51, 164 51, 164 52, 116
ΔCmax, nmol/L (N=31)
Mean [95% CI] 30 [23, 39] 28 [18, 42] 33 [24, 46] 0.486
Range 2, 87 2, 87 9, 52
Area under the curve, nmol·d/Lc
AUC56/70, Mean (N=30) 935 910 969 0.863
[95% CI] [651, 1343] [531, 1559] [563, 1668]
AUC28/35, Mean (N=31) 591 562 632 0.672
[95% CI] [448, 780] [383, 823] [398, 1003]
ΔCavg28/35 per mg dosed (nmol/L/mg)
[95% CI] 12 [10,15] 12 [8,15] 14 [10,18] 0.370

a. [25(OH)D] summary measures are geometric means with exponentiated 95% confidence intervals, unless otherwise indicated.

b. One-way analysis of variance (ANOVA) test for difference between non-pregnant and pregnant groups.

c. AUC was only estimated using data from participants with follow-up to the end of the interval of interest (i.e., 28/35 days or 56/70 days).

d. Average [25(OH)D] over the first 28 or 35 days, per mg of the single vitamin D3 dose. Arithmetic means and 95% confidence intervals reported because these estimates had an approximately normal distribution.

Roth et al.

Roth et al. Nutrition Journal 2012 11:114   doi:10.1186/1475-2891-11-114

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