Table 1 |
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Changes in [25(OH)D] following a single dose of 70,000 IU vitamin D3 in non-pregnant and pregnant women in Dhaka, Bangladesh^{a} | ||||
All participants | Non-pregnant | Pregnant | P^{b} | |
N (all participants) | 61 | 34 | 27 | |
Baseline [25(OH)D] (N=61) | ||||
Mean [95% CI] | 47 [42, 52] | 54 [47, 62] | 39 [34, 45] | 0.010 |
Range | 21, 96 | 27, 96 | 21, 95 | |
Δ[25(OH)D], Mean [95% CI], nmol/L | ||||
Day 2 (N=27) | 20 [15,25] | 24 [17, 33] | 15 [11,22] | 0.037 |
Day 4 (N=27) | 23 [18, 30] | 24 [17, 34] | 23 [16, 32] | 0.800 |
Day 7 (N=29) | 26 [21, 33] | 25 [18, 34] | 28 [20, 40] | 0.134 |
Day 21 (N=14) | 25 [18, 35] | 21 [14, 33] | 32 [20, 51] | 0.003 |
Day 56 (N=12) | 16 [11,23] | 14 [9,21] | 20 [12, 33] | 0.101 |
Participants in single-dose only groups | ||||
N (% followed more than 7 days) | 31 (51%) | 18 (53%) | 13 (48%) | |
# Specimens per participant | ||||
Median | 6 | 6 | 6 | |
Range | 3, 6 | 3, 6 | 3, 6 | |
Baseline [25(OH)D] (N=31) | ||||
Mean [95% CI] | 48 [41, 56] | 52 [42, 64] | 43 [34, 55] | 0.224 |
Range | 21, 96 | 27, 96 | 21, 95 | |
Tmax, days (N=31) | ||||
Mean [95% CI] | 11 [7,18] | 9 [4,17] | 17 [10,29] | 0.134 |
Range | 2, 70 | 2, 70 | 2, 70 | |
Cmax, nmol/L (N=31) | ||||
Mean [95% CI] | 85 [77, 93] | 87 [75, 101] | 82 [72, 92] | 0.500 |
Range | 51, 164 | 51, 164 | 52, 116 | |
ΔCmax, nmol/L (N=31) | ||||
Mean [95% CI] | 30 [23, 39] | 28 [18, 42] | 33 [24, 46] | 0.486 |
Range | 2, 87 | 2, 87 | 9, 52 | |
Area under the curve, nmol·d/L^{c} | ||||
AUC_{56/70}, Mean (N=30) | 935 | 910 | 969 | 0.863 |
[95% CI] | [651, 1343] | [531, 1559] | [563, 1668] | |
AUC_{28/35}, Mean (N=31) | 591 | 562 | 632 | 0.672 |
[95% CI] | [448, 780] | [383, 823] | [398, 1003] | |
ΔCavg_{28/35 }per mg dose^{d }(nmol/L/mg) | ||||
[95% CI] | 12 [10,15] | 12 [8,15] | 14 [10,18] | 0.370 |
^{a. }[25(OH)D] summary measures are geometric means with exponentiated 95% confidence intervals, unless otherwise indicated.
^{b. }One-way analysis of variance (ANOVA) test for difference between non-pregnant and pregnant groups.
^{c. }AUC was only estimated using data from participants with follow-up to the end of the interval of interest (i.e., 28/35 days or 56/70 days).
^{d. }Average [25(OH)D] over the first 28 or 35 days, per mg of the single vitamin D3 dose. Arithmetic means and 95% confidence intervals reported because these estimates had an approximately normal distribution.
Roth et al.
Roth et al. Nutrition Journal 2012 11:114 doi:10.1186/1475-2891-11-114