Table 3

Associations (adjusted OR, 95%CI) of total energy, macronutrients, and alcohol intakes with CRC risk, CRC case-control study in NL and ON

Intakes of total energy, macronutrients, and alcohol

Quintiles of intakes

p-trendb


Q1e

Q3e

Q5e


Total energy

No. of cases/controls

313/537

343/505

404/443

Median intake (kcal/day)

1348.5

2109.3

3308.9

ORa (95% CI)

1.00

1.19(0.92,1.53)

1.56*(1.21,2.01)

0.02

Protein

No. of cases/controls

372/479

334/513

335/512

Median intake (g/day)

68.4

85.6

106.7

ORa (95% CI)

1.00

0.88(0.70,1.11)

0.85*(0.69,1.00)

0.06

Carbohydrate

No. of cases/controls

392/458

332/516

334/513

Median intake (g/day)

229.1

282.6

341.5

ORa (95% CI)

1.00

0.84(0.67,1.02)

0.81*(0.63,1.00)

0.05

Total Fat

No. of cases/controls

344/506

362/487

372/475

Median intake (g/day)

60.1

80.5

102.8

ORa (95% CI)

1.00

1.18(0.94,1.50)

0.96(0.75,1.22)

0.71

Total dietary fibre

No. of cases/controls

388/462

355/493

308/539

Median intake (g/day)

15.1

23.7

35.2

ORa (95% CI)

1.00

0.97(0.77,1.23)

0.84*(0.67,0.99)

0.04

Saturated Fatty Acids

No. of cases/controls

346/504

331/517

378/469

Median intake (g/day)

19.0

26.6

35.2

ORa (95% CI)

1.00

1.03(0.81,1.31)

1.00(0.79,1.26)

0.80

Monounsaturated Fatty Acids

No. of cases/controls

341/509

342/506

371/476

Median intake (g/day)

21.2

29.1

38.2

ORa (95% CI)

1.00

1.07(0.84,1.35)

0.99(0.78,1.26)

0.70

Polyunsaturated Fatty Acids

No. of cases/controls

357/493

343/505

372/475

Median intake (g/day)

11.6

16.4

22.4

ORa (95% CI)

1.00

1.03(0.81,1.30)

0.98(0.77,1.23)

0.47

Cholesterol

No. of cases/controls

342/508

339/509

380/467

Median intake (mg/day)

178.8

265.8

392.0

ORa (95% CI)

1.00

0.84(0.65,1.07)

1.00(0.79,1.28)

0.88

Alcohol

No. of cases/controls

382/467

309/539

344/503

Median intake (g/day)

0

13.6

182.8

ORa (95% CI)

1.00

0.88(0.67,1.17)

1.17(0.85,1.61)

0.38


a Adjusted for total energy intake. Other potential confounders included age, sex, BMI, physical activity (METs/week), family history of CRC, polyps, diabetes, reported colon screening procedure, cigarette smoking, alcohol drinking, education attainment, household income, marital status, regular use of NSAID, regular use of multivitamin supplements, regular use of folate supplement, regular use of calcium supplement, reported HRT (females only), province of residence, and intakes of fruits, vegetables, and red meat. Variables were included in the final model based on a ≥ 10% alternation in the parameter coefficient of interest.

b Two-sided p value for test of linear trend was calculated by using median values for each quintile of intake.

e Q1 for quintile 1, Q3 for quintile 3, Q5 for quintile

* Significant different from reference category, p ≤ 0.05

Sun et al. Nutrition Journal 2012 11:18   doi:10.1186/1475-2891-11-18

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