Table 2

Response of plasma homocysteine to different doses and duration of folic acid supplementation by MTHFR C677T genotypes

N

Homocysteine, μmol/L1

Percent relative change of homocysteine2

Difference in change of Homocysteine at 4 weeks by genotypes3

Difference in change of Homocysteine at 8 weeks by genotypes3


baseline

4 weeks

8 weeks

β

SE

P

β

SE

P


Control

CC

41

11.6(1.4)[11.3]

11.9(1.3)[11.8]

11.8(1.4)[11.3]

3.35(13.7)

2.2(14.0)

ref

ref

.

CT

73

11.0(1.4)[11.1]

11.2(1.4)[11.3]

11.3(1.4)[11.1]

2.25(13.2)

3.1(14.0)

-3.69

2.94

0.209

-1.80

3.45

0.601

TT

38

18.1(1.9)[14.7] #

18.0(1.9)[15.6] #

18.1(1.8)[16.5] #

1.19(19.7)

3.3(27.0)

-4.05

3.33

0.225

-0.52

3.91

0.895

Total

152

12.7(1.6)[12.0]

12.8(1.6)[11.7]

12.8(1.6)[12.0]

2.3(15.1)

2.9(18.0)

Low FA

CC

34

11.0(1.3)[11.0]

9.9(1.3)[9.4]*

9.8(1.3)[9.5] *

-8.8(13.0)

-9.9(14.9)

ref

ref

CT

79

12.6(1.5)[11.4]

11.5(1.4)[11.1] *#

11.2(1.4)[10.7] *#$

-7.6(15.4)

-9.7(16.8)

2.14

3.35

0.523

2.52

3.88

0.516

TT

34

17.5(1.8)[17.2] #

15.2(1.7)[14.2] *#

14.8(1.6)[14.2] *#

-10.6(21.3)

-11.2(27.1)

-1.16

3.95

0.769

0.06

4.58

0.989

Total

147

13.2(1.6)[11.6]

11.8(1.5)[11.3] *

11.6(1.5)[10.8] *$%

-8.6(16.4) %

-10.1(19.1) %

High FA

CC

39

11.0(1.4)[10.8]

10.2(1.4)[10.1] *

9.7(1.4)[9.8] *$

-5.9(14.2)

-10.8(11.1)

ref

ref

CT

69

12.3(1.3)[12.0]

10.8(1.3)[11.0] *

10.7(1.3)[10.5] *

-11.2(14.5)

-11.2(16.5)

-6.21

3.19

0.052

-0.47

3.39

0.890

TT

38

20.8(1.8)[19.6] #

15.8(1.6)[14.2] *#

15.4(1.6)[14.1] *#

-20.3(22.2) #

-22.0(23.8) #

-15.51

3.72

< 0.001

-11.12

3.95

0.005

Total

146

13.7(1.6)[12.7]

11.7(1.5)[11.4] *

11.5(1.5)[10.8] *%

-12.1(17.5) %

-13.9(18.1) %


1Geometric mean (anti-log SD), median in brackets;

2[(Homocysteine after treatment - homocysteine at baseline)/(homocysteine at baseline)]*100, Mean(SD);

3Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL-C, TC, FPG, folate, folate change, MTR A2756G polymorphism and study centers;

*Significantly different from baseline, P < 0.05; $Significantly different from week 4, P < 0.05;

#Significantly different from the CC genotype, P < 0.05; %Significantly different from control group, P < 0.05.

Qin et al. Nutrition Journal 2012 11:2   doi:10.1186/1475-2891-11-2

Open Data