Table 2 |
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|
Response of plasma homocysteine to different doses and duration of folic acid supplementation by MTHFR C677T genotypes |
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|
N |
Homocysteine, μmol/L1 Percent relative change of homocysteine2 |
Difference in change of Homocysteine at 4 weeks by genotypes3 |
Difference in change of Homocysteine at 8 weeks by genotypes3 |
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|
|
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|
baseline |
4 weeks |
8 weeks |
β |
SE |
P |
β |
SE |
P |
||
|
|
||||||||||
|
Control |
||||||||||
|
CC |
41 |
11.6(1.4)[11.3] |
11.9(1.3)[11.8] |
11.8(1.4)[11.3] |
||||||
|
3.35(13.7) |
2.2(14.0) |
ref |
ref |
. |
||||||
|
CT |
73 |
11.0(1.4)[11.1] |
11.2(1.4)[11.3] |
11.3(1.4)[11.1] |
||||||
|
2.25(13.2) |
3.1(14.0) |
-3.69 |
2.94 |
0.209 |
-1.80 |
3.45 |
0.601 |
|||
|
TT |
38 |
18.1(1.9)[14.7] # |
18.0(1.9)[15.6] # |
18.1(1.8)[16.5] # |
||||||
|
1.19(19.7) |
3.3(27.0) |
-4.05 |
3.33 |
0.225 |
-0.52 |
3.91 |
0.895 |
|||
|
Total |
152 |
12.7(1.6)[12.0] |
12.8(1.6)[11.7] |
12.8(1.6)[12.0] |
||||||
|
2.3(15.1) |
2.9(18.0) |
|||||||||
|
Low FA |
||||||||||
|
CC |
34 |
11.0(1.3)[11.0] |
9.9(1.3)[9.4]* |
9.8(1.3)[9.5] * |
||||||
|
-8.8(13.0) |
-9.9(14.9) |
ref |
ref |
|||||||
|
CT |
79 |
12.6(1.5)[11.4] |
11.5(1.4)[11.1] *# |
11.2(1.4)[10.7] *#$ |
||||||
|
-7.6(15.4) |
-9.7(16.8) |
2.14 |
3.35 |
0.523 |
2.52 |
3.88 |
0.516 |
|||
|
TT |
34 |
17.5(1.8)[17.2] # |
15.2(1.7)[14.2] *# |
14.8(1.6)[14.2] *# |
||||||
|
-10.6(21.3) |
-11.2(27.1) |
-1.16 |
3.95 |
0.769 |
0.06 |
4.58 |
0.989 |
|||
|
Total |
147 |
13.2(1.6)[11.6] |
11.8(1.5)[11.3] * |
11.6(1.5)[10.8] *$% |
||||||
|
-8.6(16.4) % |
-10.1(19.1) % |
|||||||||
|
High FA |
||||||||||
|
CC |
39 |
11.0(1.4)[10.8] |
10.2(1.4)[10.1] * |
9.7(1.4)[9.8] *$ |
||||||
|
-5.9(14.2) |
-10.8(11.1) |
ref |
ref |
|||||||
|
CT |
69 |
12.3(1.3)[12.0] |
10.8(1.3)[11.0] * |
10.7(1.3)[10.5] * |
||||||
|
-11.2(14.5) |
-11.2(16.5) |
-6.21 |
3.19 |
0.052 |
-0.47 |
3.39 |
0.890 |
|||
|
TT |
38 |
20.8(1.8)[19.6] # |
15.8(1.6)[14.2] *# |
15.4(1.6)[14.1] *# |
||||||
|
-20.3(22.2) # |
-22.0(23.8) # |
-15.51 |
3.72 |
< 0.001 |
-11.12 |
3.95 |
0.005 |
|||
|
Total |
146 |
13.7(1.6)[12.7] |
11.7(1.5)[11.4] * |
11.5(1.5)[10.8] *% |
||||||
|
-12.1(17.5) % |
-13.9(18.1) % |
|||||||||
|
|
||||||||||
|
1Geometric mean (anti-log SD), median in brackets; 2[(Homocysteine after treatment - homocysteine at baseline)/(homocysteine at baseline)]*100, Mean(SD); 3Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL-C, TC, FPG, folate, folate change, MTR A2756G polymorphism and study centers; *Significantly different from baseline, P < 0.05; $Significantly different from week 4, P < 0.05; #Significantly different from the CC genotype, P < 0.05; %Significantly different from control group, P < 0.05. |
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|
Qin et al. Nutrition Journal 2012 11:2 doi:10.1186/1475-2891-11-2 |
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