Table 3

Response of plasma Homocysteine to different doses and duration of folic acid supplementation by MTR A2756G genotypes

N

Homocysteine, μmol/L1

Percent relative change of homocysteine2

Difference in change of Homocysteine at 4 weeks by genotypes3

Difference in change of Homocysteine at 8 weeks by genotypes3

baseline

4 weeks

8 weeks

β

SE

P

β

SE

P


Control

AA

130

12.8(1.6)[12.0]

12.9(1.6)[11.7]

12.9(1.6)[12.0]

1.7(15.1)

2.33(17.7)

ref

ref

.

AG/GG

22

12.1(1.5)[11.7]

12.6(6.8)[1.6]

12.6(1.5)[12.2]

5.8(15.2)

6.32(20.1)

5.17

3.50

0.139

6.08

4.10

0.138

Total

152

12.7(1.6)[12.0]

12.8(1.6)[11.7]

12.8(1.6)[12.0]

2.3(15.1)

2.9(18.0)

Low FA

AA

116

12.9(1.6)[11.5]

11.5(1.5)[11.1]*

11.3(1.5)[10.6] *

-9.4(16.5)

-10.2(19.4)

ref

ref

AG/GG

31

14.1(1.5)[14.5]

13.1(1.5)[12.3]

12.5(1.5)[12.3] *$

-5.4 (15.9)

-9.6(18.3)

3.73

3.33

0.262

-0.06

3.86

0.989

Total

147

13.2(1.6)[11.6]

11.8(1.5)[11.3] *

11.6(1.5)[10.8] *$%

-8.6(16.4) %

-10.1(19.1) %

High FA

AA

119

13.7(1.6)[12.7]

11.8(1.5)[11.4] *

11.5(1.4)[10.8] *$

-12.3(16.2)

-14.4(17.3)

ref

ref

AG/GG

27

13.5(1.8)[12.9]

11.6(1.5)[11.4] *

11.5(1.5)[10.7] *

-11.5(22.7)

-11.9(21.5)

1.30

3.39

0.700

2.72

3.60

0.450

Total

146

13.7(1.6)[12.7]

11.7(1.5)[11.4] *

11.5(1.5)[10.8] *%

-12.1(17.5) %

-13.9(18.1) %


1Geometric mean (anti-log SD), median in brackets;

2[(Homocysteine after treatment - homocysteine at baseline)/( homocysteine at baseline)]*100, Mean(SD);

3Regression model was adjusted for age, sex, BMI, baseline SBP, DBP, creatinine, TG, HDL, TC, FPG, MTHFR C677T polymorphism and study centers;

*Significantly different from baseline, P < 0.05; $Significantly different from week 4, P < 0.05;

%Significantly different from control group, P < 0.05.

Qin et al. Nutrition Journal 2012 11:2   doi:10.1186/1475-2891-11-2

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