Open Access Highly Accessed Open Badges Review

Gut-central nervous system axis is a target for nutritional therapies

Gustavo D Pimentel16*, Thayana O Micheletti2, Fernanda Pace1, José C Rosa3, Ronaldo VT Santos4 and Fabio S Lira5

Author Affiliations

1 Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil

2 Faculty of Applied Science, State University of Campinas (UNICAMP), Limeira, SP, Brazil

3 Department of Physiology and Biophysics, Institute of Biomedical Sciences I, University of São Paulo (USP), São Paulo, SP, Brazil

4 Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil

5 Laboratory of Exercise Biochemistry and Physiology, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

6 José Caetano de Lima, 682. Bairro Junqueira, Lins MA: 16403-162, SP, Brazil

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Nutrition Journal 2012, 11:22  doi:10.1186/1475-2891-11-22

Published: 10 April 2012


Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the "appetite centre" and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.

Gut; Central nervous system; Nutrition; Diet; Appetite; Inflammatory disease