Table 4

Effects of the timing of enteral feeding initiation (early feeding) on different clinical and nutritional outcomes
Measured outcomes APACHE II <20 APACHE II ≥20
(n = 47) (n = 61)
Multiple linear regression β S.E. p β S.E. p
Clinical outcomes
 Frequency of feeding complications (times/d) −0.045 0.070 0.526 0.084 0.042 0.05
 Length of ICU stay (d) −0.003 3.350 0.999 9.401 2.785 0.001
 Length of hospital stay (d) −10.731 8.187 0.197 10.654 6.155 0.089
Nutritional outcomes
 % of target caloric intake −0.230 7.832 0.977 4.509 6.709 0.504
 % of target protein intake −0.444 8.898 0.960 1.412 8.777 0.873
 Albumin on 7th feeding day (g/L) 92.569 183.796 0.618 220.398 153.507 0.158
 Prealbumin on 4th feeding day (mg/dL) −0.574 2.527 0.821 1.961 1.874 0.300
 Prealbumin on 7th feeding day (mg/dL) −1.882 2.916 0.524 3.110 1.688 0.072
 24-h UUN on 14th feeding day (g/d) 6.455 4.435 0.180 5.343 1.730 0.006
 24-h UUN on 21st feeding day (g/d) 5.398 0.516 0.061 6.816 1.864 0.008
 NB on 7th feeding day (g/d) −8.615 2.219 0.001 −3.687 2.116 0.089
 NB on 14th feeding day (g/d) −5.954 4.407 0.210 −7.126 2.194 0.004
Logistic regression Adjusted OR 95 % CI p Adjusted OR 95 % CI p
Clinical outcomes
 VAP 2.697 0.38-19.0 0.319 2.062 0.56-7.56 0.275
 Hospital mortality 0.400 0.09-1.77 0.227 1.083 0.36-3.29 0.888
 Diarrhea 0.519 0.09-2.99 0.463 9.455 1.81-49.44 0.008
 GI bleeding 0.433 0.03-6.58 0.547 7.075 1.24-40.32 0.028

APACHE, Acute Physiology and Chronic Health Evaluation; NB, nitrogen balance; UUN, urinary urea nitrogen; VAP, ventilator-associated pneumonia; ICU, intensive care unit.

Multiple linear or logistic regression for examining the effects of the timing of enteral feeding initiation (X) on measured outcomes (Y) after adjusting for gender, age and illness severity. Coding for the timing of enteral feeding initiation (X): early feeding = 1, late feeding = 0.

Huang et al.

Huang et al. Nutrition Journal 2012 11:30   doi:10.1186/1475-2891-11-30

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