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The effects of four hypocaloric diets containing different levels of sucrose or high fructose corn syrup on weight loss and related parameters

Joshua Lowndes1, Diana Kawiecki1, Sabrina Pardo1, Von Nguyen1, Kathleen J Melanson2, Zhiping Yu1 and James M Rippe1*

Author Affiliations

1 Rippe Lifestyle Institute, 215 Celebration Place, Suite 300, Celebration, FL 34747, USA

2 Rhode Island University, 202 A Ranger Hall, Kingston, RI, 02881, USA

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Nutrition Journal 2012, 11:55  doi:10.1186/1475-2891-11-55

Published: 6 August 2012



The replacement of sucrose with HFCS in food products has been suggested as playing a role in the development of obesity as a public health issue. The objective of this study was to examine the effects of four equally hypocaloric diets containing different levels of sucrose or high fructose corn syrup (HFCS).


This was a randomized, prospective, double blind trial, with overweight/obese participants measured for body composition and blood chemistry before and after the completion of 12 weeks following a hypocaloric diet. The average caloric deficit achieved on the hypocaloric diets was 309 kcal.


Reductions were observed in all measures of adiposity including body mass, BMI,% body fat, waist circumference and fat mass for all four hypocaloric groups, as well as reductions in the exercise only group for body mass, BMI and waist circumference.


Similar decreases in weight and indices of adiposity are observed when overweight or obese individuals are fed hypocaloric diets containing levels of sucrose or high fructose corn syrup typically consumed by adults in the United States.

High fructose corn syrup; Hypocaloric diet; Weight loss; Dietary counseling