Table 4

A summary of four included prebiotic studies
Boehm 2002 [[36] Indrio 2009 [[43] Kapiki 2007 [[45] Mihatsch 2006 [[44]
Location of study Milan, Italy University of Bari, Policinico, Italy Athens, Greece Ulm University, Germany
Participants - entry criteria <32 weeks gestation Healthy preterm newborns ≤ 36 weeks gestation < 1500 g birth weight
Number of study participants Study group = 15, Placebo = 15 Study group = 10 , Placebo = 10 Study group = 36, Placebo = 20 Study group = 10, Placebo = 10
Prebiotic used GOS 90%, FOS 10% scGOS, lcFOS at ratio 9:1 FOS GOS, FOS
Dose of prebiotic 1g/dl 0.8 g/dl 0.4g/100ml 1g/dl
Placebo Maltodextrin Maltodextrin Maltodextrin Maltodextrin
Dose of placebo 1 g/dl 0.8 g/dl 0.4 g 1.8 / 90 ml
Treatment initiation When enteral feed ≥ 80 mls /kg/day was tolerated Not clear Exclusively formula fed at start of study At full enteral feed at start of study
Treatment duration 28 days 15 days 14 days 15 days
Reported Outcomes
Growth parameters Weight gain, linear growth Weight gain, linear growth, head growth Weight gain, linear growth, head growth Weight gain
Timing and duration of measurement of growth parameters Measured on days 1, 7, 14, 28 Measured before start of study, days 3, 5, 15 Measured on days 1, 7, 14 Weight gain: reported as “Average weight gain during study.”
Feed tolerance Number of days to full enteral feed, maximal enteral feed Number of days to full enteral feed, maximal enteral feed Number of days to full enteral feed Number of days to full enteral feed, maximal enteral feed
Stool characteristics Stooling frequency, consistency Stooling frequency, consistency Stool viscosity, Stooling frequency, consistency
Changes in gastrointestinal microflora cfu bifidobacteria cfu bifidobacteria, pathogens

Mugambi et al.

Mugambi et al. Nutrition Journal 2012 11:58   doi:10.1186/1475-2891-11-58

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