Table 5

A summary of five on-going studies
Jacobs 2007 [[46] Lozano 2008 [[47] Al-Hosni 2010 [[48] Patole 2009 [[49] Underwood 2009 [[50]
Location of study Australia Colombia USA Australia USA
Participants - inclusion criteria <32 weeks gestation, <1500 g birth weight, 1–3 days old Birth weight <2000 grams, < 48 hours of age, admission in NICU, Hemodynamic-ally stable Extremely Low Birth weight infants: < 1000 grams, 1 to 14 old, intention to start enteral feeds 32 weeks Gestation and 6 days, <1500g birth weight, ready to commence on enteral feeds for up to 12 hours < 500grams birth weight, age less than 33 weeks gestation, exclusively formula fed
Probiotic bacteria used Bifidobacteriuminfantis, BifidobacteriumBifidus, Streptococcus thermophilus Lactobacillus reuteri DSM 17938 Lactobacillus rhamnosus GG, Bifidobacteriuminfantis Lactobacillus acidophilus 375 million, bifidobacteriumbifidum, bifidobacteria longus 1. ProlactPlus
2. GOS
3. Bifidobacteriuminfantis
4. Bifidobacteriumanimalis
Dose 1X109 1X108 CFU in 5 drops of oil suspension 1/ day until discharge. L rhamnosus: 500 million cfu, B.infantis: 500 million cfu L. acidophilus:375 m organisms, B bifidum, B. longus: 125 million organisms 1. week 1 95:5 to week 5 75:25
2. week: 0.25g/dL, to week 5: 2.0 g/dL
3. week 1: 5X107, to week 5: 4.2 X109
4. week 1: 5X107, to week 5: 4.2 X109
Start date of study July- 2007 August 2008 February 2008 June 2009 June 2009
Reported Outcomes Sepsis, Sepsis Average weight gain Sepsis Fecal microflora
NEC NEC Growth velocity NEC
Death Death Feed tolerance All-cause mortality
Frequency of events Volume of feed/day Time to reach full feeds (150 mls/kg/day)
Length of hospital admission Gut colonisation by probiotic
Number of antibiotic courses
Days to full enteral feeds

Mugambi et al.

Mugambi et al. Nutrition Journal 2012 11:58   doi:10.1186/1475-2891-11-58

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