The diagram shows the enzyme points (in cycle) on which the effects of n-3 PUFA might operate in the homocysteine metabolic pathway of relevance. The critical genes in cycle were determined in present study. MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase; MAT: methionine adenosyl transferase; SAHH: S-adenosylhomocysteine hydrolases; CBS: Cystathionine β-synthase; CSE: Cystathionine γ-lyase; MTHFR: Methylenetetrahydrafolate reductase; BHMT: Betaine-homocysteine methyltransferase; DMG: Dimethylglycine; 5, 10-CH3-THF: 5, 10-Methylene-Tetrahydrofolate; 5-CH3-THF: 5-Methyl-Tetrahydrofolate; THF: Tetrahydrofolate; SHMT: Serine hydroxymethyl transferase; Pi: Orthophosphate; PPi: Pyrophosphate.
Huang et al. Nutrition Journal 2012 11:6 doi:10.1186/1475-2891-11-6