Table 3

The predicted transcription factors binding to fatty acid-responsive element in the promoter of the gene involved in Hcy metabolism

Gene

GeneID

Transcript

Factor

Name(s)

Chrom

Start

End


MTR

4548

NM_000254

MA0066

PPARG

chr1

236,956,831

236,956,850

MTR

4548

NM_000254

MA0061

NF-kappaB

chr1

236,958,560

236,958,569

HHCY

191

NM_000687

MA0061

NF-kappaB

chr20

32891257

32891266

HHCY

191

NM_000687

M00242

PPARalpha:RXRalpha

chr20

32891807

32891826

HHCY

191

NM_000687

M00964

PXR, CAR, LXR, FXR

chr20

32892802

32892813

HHCY

191

NM_000687

T00720

RAR-gamma

chr20

32891787

32891797

HHCY

191

NM_000687

MA0074

RXRA::VDR

chr20

32891381

32891395

CSE

1491

NM_153742

M00774

NF-kappaB

chr1

70876211

70876222

CSE

1491

NM_153742

M00762

PPAR, HNF-4, COUP,

chr1

70875793

70875805

CSE

1491

NM_153742

M00518

PPARalpha:RXRalpha

chr1

70876539

70876552

CSE

1491

NM_153742

MA0065

PPARG::RXRA

chr1

70876537

70876553

CSE

1491

NM_153742

MA0074

RXRA::VDR

chr1

70875356

70875369

CSE

1491

NM_153742

T01331

RXR-alpha

chr1

70876645

70876657

CBS

875

NM_000071

MA0061

NF-kappaB

chr21

44496816

44496825

CBS

875

NM_000071

T00694

PPAR-alpha

chr21

44496841

44496851

CBS

875

NM_000071

MA0073

RREB1

chr21

44496183

44496202

CBS

875

NM_000071

MA0074

RXRA::VDR

chr21

44496362

44496376

CBS

875

NM_000071

T01349

RXR-beta

chr21

44496925

44496932

MAT1A

4143

NM_000429

T05257

CAR2:RXR-alpha

chr10

82051245

82051257

MAT1A

4143

NM_000429

M00631

FXR/RXR-alpha

chr10

82050669

82050682

MAT1A

4143

NM_000429

MA0061

NF-kappaB

chr10

82049620

82049629

MAT1A

4143

NM_000429

MA0105

NFKB1

chr10

82049504

82049514

MAT1A

4143

NM_000429

T02529

PPAR-gamma1

chr10

82051368

82051378

MAT1A

4143

NM_000429

MA0074

RXRA::VDR

chr10

82050026

82050040

MAT1A

4143

NM_000429

T01331

RXR-alpha

chr10

82050924

82050936

MTHFR

4524

NM_005957

MA0066

PPARG

chr1

11866220

11866239

MTHFR

4524

NM_005957

T05313

FXR:RXR-alpha

chr1

11867028

11867042

MTHFR

4524

NM_005957

M00774

NF-kappaB

chr1

11866612

11866623

MTHFR

4524

NM_005957

M00518

PPARalpha:RXRalpha

chr1

11867952

11867966

MTHFR

4524

NM_005957

MA0065

PPARG::RXRA

chr1

11867331

11867347

MTHFR

4524

NM_005957

T02529

PPAR-gamma1

chr1

11867417

11867427

MTHFR

4524

NM_005957

M00964

PXR, CAR, LXR, FXR

chr1

11866787

11866798


The predicted transcription factors (RXR-alpha) binding to n-3 PUFA-RE in the promoter of MTHFR, CSE, and MAT using web based software Mapper: http://genome.ufl.edu/mapper/ webcite.

Huang et al. Nutrition Journal 2012 11:6   doi:10.1186/1475-2891-11-6

Open Data