Table 1

Reduction in testosterone glucuronidation activity of UGT2B17 by the addition of phenolic compounds
Initial testosterone concentration (μM) Test sample concentration Test sample concentration (μM) Glucuronidation % of control (±SD)
Screening study
100 4-Ethylphenol 750 78.9 ±1.131
50 4-Ethylphenol 750 57.3 ±13.548
100 Gallic acid 250 91.01 ±10.946
100 Caffeic acid 250 78.65 ±5.685
100 p-Coumaric Acid 250 NA
100 Chlorogenic Acid 250 NA
100 Quercetin 250 28.01 ±2.800
Low concentration study
20 Quercetin 50 65.62 ±14.298
20 Quercetin 20 79.93 ±11.370
20 Quercetin 2 82.42 ±7.057
30 Quercetin 2 97.69 ±9.235
20 Quercetin 1.5 91.37 ±7.806

The results display the percentage change in the glucuronidation of testosterone over 60 mins by UGT2B17 in comparison to the uninhibited control.

Jenkinson et al.

Jenkinson et al. Nutrition Journal 2012 11:67   doi:10.1186/1475-2891-11-67

Open Data