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Open Access Research

Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients

Maria do Socoro Ramos de Queiroz1*, Daniele Idalino Janebro2, Maria Auxiliadora Lins da Cunha1, Josimar dos Santos Medeiros1, Armando UO Sabaa-Srur3, Margareth de Fatima FM Diniz4 and Silvana Cristina dos Santos1

Author Affiliations

1 Department of Pharmacy, Paraíba State University, Zip Code: 58429-600, Campina Grande, PB, Brazil

2 Maurício de Nassau College, Zip Code 58410-050, Campina Grande, PB, Brazil

3 Department of Nutrition, Federal University of Rio de Janeiro, Zip Code 21949-900, Rio de Janeiro, PB, Brazil

4 Department of Pharmacy, Paraíba State University, Zip Code: 58051-970, Campina Grande, PB, Brazil

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Nutrition Journal 2012, 11:89  doi:10.1186/1475-2891-11-89

Published: 22 October 2012



A study with the yellow passion fruit peel flour showed positive action in blood glucose control as therapies’ adjuvant in patients with type 2 diabetes mellitus. Therefore, we evaluated its effect on insulin sensitivity since there is a quest for studies that focus at better understanding of insulin resistance aspects in diabetic patients. Furthermore its relationship with chronic complications can also give good prospects for alternative treatments.


A total of 43 type 2 diabetes volunteers (28 females and 15 males) ingested 30 g/day of the yellow passion fruit peel flour for two months. The levels of blood glucose and fasting insulin, HOMA index and glycated hemoglobin were measured for each patient before and after dietary supplementation.


There was a significant difference in the fasting blood glucose values (P = 0.000) and glycated hemoglobin (P = 0.032) after supplementation. It was also seen a reduction in HOMA IR (P = 0.005) in the supplemented group, however it was not observed changes in insulin values for females. HOMA beta (P = 0.000) showed significant increase in its values for the studied group.


The supplementation used decreased insulin resistance in type 2 diabetic patients, suggesting a positive action in blood glucose control as adjuvant therapy in conventional treatments.