Table 1

Selected milk-derived miRs and their potential impact on metabolism
Milk-derived miR Ref. miR function in metabolism Ref.
miR-21 50 miR-21: Inhibition of various tumor suppressor gene mRNAs (PTEN, Spouty1, Sprouty2, PDCD4) [63-72,75]
Increased adipogenesis [100-102]
miR-29a 54 miR-29a: Down-regulation of Insig-1 with increased lipogenesis and adipocyte differentiation [106]
[107,108]
miR-29b 51 miR-29b: Reduction of BCKD and reduced BCAA catabolism [111]
[110]
miR-103 51 miR-103: Increased adipogenesis [100,105]
miR-155 51 miR-155: Reduction of brown adipose tissue and thermogenesis [109]
Let-7a, b, c, f 51 Let-7: overexpression results in insulin resistance and disturbed glucose homeostasis [120,122]

Melnik et al.

Melnik et al. Nutrition Journal 2013 12:103   doi:10.1186/1475-2891-12-103

Open Data