Table 3

Median (IQR) for anthropometric indices, biochemical and laboratory markers at baseline, 6 months and the median (IQR) % change calculated between baseline and 6 months follow-up
Nutritional supplement Control
Baseline 6 months % change# Baseline 6 months % change# p value
N = 19 N = 11 N = 19 N = 15
Clinical characteristics
Weight (kg) 53.4 (45.6 – 59.0) 59.6 (48.0 – 65.4) 12.7 (7.0 – 25.3) 52.8 (48.7 – 60.4) 54.0 (50.2 – 61.3) 4.9 (−1.6 – 11.2) 0.047
Body mass index (BMI; kg/m2) 20.4 (18.0 – 22.4) 22.1 (19.9 – 24.3) 7.8 (7.0 – 14.4) 19.3 (18.4 – 21.3) 20.0 (18.5 – 23.7) 5.5 (0.5 – 10.9) 0.007
Systolic blood pressure (mmHg) 104 (90 – 125) 111 (100 – 119) 6.7 (−10.1 – 35.6) 111 (107 – 127) 118 (99 – 134) −0.8 (−7.5 – 10.0) 0.273
Diastolic blood pressure (mmHg) 69 (46 – 76) 70 (59 – 75) 2.9 (−22.2 – 45.0) 71 (66 – 84) 73 (63 – 88) 0.1 (−7.6 – 4.5) 0.685
CD4 (cells/mm3) 60 (12 – 105)* 167 (154 – 293) 83.0 (76.4 – 93.1) 107 (63 – 165)* 233 (152 – 359) 46.4 (20.7 – 60.4) 0.002
≤100 cells/mm3 34 (12 – 60) 157 (107 – 246) 88.9 (79.3 – 95.3) 63 (35 – 86) 189 (100 – 251) 56.9 (49.0 – 81.6) 0.039
>100 – 350 cells/mm3 117 (105 – 135) 259 (225 – 293) 56.6 (53.8 – 59.4) 148 (125 – 257) 324 (233 – 377) 21.1 (20.4 – 34.8) 0.018
Hemoglobin (g/dL) 10.3 (9.0 – 11.3)* 12.5 (11.1 – 13.6) 9.5 (1.1 – 40.4) 13.1 (11.1 – 14.7)* 13.6 (12.8 – 14.7) 1.0 (−1.5 – 7.6) 0.026
Mean cell volume (fL) 85.0 (78.4 – 89.9) 93.7 (81.7 – 96.4) 6.4 (4.7 – 7.2) 91.3 (84.0 – 94.8) 99.3 (91.8 – 103.4) 8.1 (3.7 – 9.0) 0.608
Red blood cells (x1012/L) 3.7 (3.1 – 3.9)* 4.1 (3.7 – 4.1) 7.0 (−4.8 – 34.3) 4.3 (3.9 – 4.9)* 4.1 (3.7 – 4.6) −4.7 (−11.3 – 3.8) 0.043
White blood cells (x109/L) 3.4 (2.7 – 5.1) 4.5 (3.2 – 4.7) 28.6 (21.6 – 52.4) 4.4 (3.3 – 5.5) 3.7 (3.4 – 5.0) −2.8 (−34.2 – 29.3) 0.035
Platelets (x109/L) 277 (210 – 326) 272 (235 – 322) 11.1 (−16.3 – 23.1) 231 (152 – 351) 256 (184 – 362) 5.6 (−14.9 – 21.1) 0.787
Anthropometric indexes
Fat (kg) 10.6 (10.0 – 17.7) 12.8 (11.4 – 22.9) 23.3 (−6.3 – 43.9) 11.1 (5.5 – 15.5) 11.9 (9.5 – 20.6) 18.4 (10.2 – 80.5) 0.375
Fat Free Mass (FFM; kg) 38.0 (34.2 – 43.1) 42.5 (35.8 – 50.9) 16.7 (2.7 – 25.8) 41.7 (39.1 – 47.1) 39.8 (35.5 – 43.1) −3.5 (−9.9 – 4.1) 0.036
Total Body Water (TBW; kg) 27.2 (23.5 – 30.4) 27.5 (24.1 – 36.4) 13.0 (2.6 – 26.1) 30.0 (25.8 – 36.3) 27.8 (24.2 – 31.3) −1.9 (−15.6 – 5.9) 0.039
Intracellular Water (ICW; kg) 14.4 (12.5 – 17.3) 15.9 (13.2 – 21.3) 16.1 (4.3 – 28.5) 17.9 (14.7 – 19.2) 15.9 (13.1 – 18.8) −4.1 (−15.3 – 1.6) 0.011
Extracellular Water (ECW; kg) 12.0 (10.6 – 14.1) 12.9 (11.5 – 15.9) 1.6 (3.8 – 23.7) 12.5 (10.9 – 16.6) 11.7 (10.8 – 15.1) −1.3 (−16.6 – 2.6) 0.028
Phase angle 6.1 (5.1 – 6.9) 6.6 (6.2 – 7.3) 25.9 (4.8 – 39.4) 6.8 (6.3 – 7.3) 6.7 (5.9 – 7.8) −1.5 (−10.8 – 25.8) 0.063
Biochemistry
Albumin (g/L) 35 (33 – 37) 40 (39 – 42) 15.6 (5.4 – 20.0) 36 (32 – 42) 42 (39 – 42) 11.8 (−2.3 – 25.7) 0.700
Pre-albumin (g/L) 0.22 (0.16 – 0.24) 0.26 (0.23 – 0.28) 21.7 (16.7 – 38.9) 0.21 (0.14 – 0.25) 0.27 (0.25 – 0.34) 18.0 (4.5 – 54.2) 0.892
Alanine transaminase (ALT;IU/L) 29 (15 – 35) 33 (19 – 41) −15.2 (−40.4 – 90.0) 26 (19 – 38) 35 (22 – 84) 36.4 (7.7 – 117.6) 0.173
Calcium (mmol/L) 2.2 (2.0 – 2.2) 2.2 (2.2 – 2.3) 3.6 (−0.5 – 9.3) 2.2 (2.0 – 2.3) 2.2 (2.1 – 2.3) 3.9 (−3.0 – 7.9) 0.766
Selenium (ug/L) 64 (52 – 79) 81 (69 – 116) 8.9 (−11.1 – 150.4) 71 (53 – 86) 95 (78 – 112) 38.1 (−6.7 – 86.8) 0.968
Magnesium (mmol/L) 0.76 (0.74 – 0.82) 0.77 (0.73 – 0.83) 2.7 (−3.9 – 9.2) 0.76 (0.70 – 0.84) 0.76 (0.73 – 0.82) 0.0 (−2.6 – 4.3) 0.643
Iron (umol/L) 8.2 (5.4 – 11.9) 11.3 (6.7 – 11.8) 1.3 (−42.2 – 79.7) 10.8 (6.9 – 16.1) 13.2 (12.1 – 18.9) 10.9 (−23.7 – 57.7) 0.558
Ferritin (ug/L) 329 (162 – 746) 26 (23 – 100) −90.3 (−96.9 – -50.3) 141 (58 – 366) 55 (23 – 76) −48.9 (−79.3 – -36.8) 0.045
Saturation transferrin (%) 16 (8 – 23) 13 (10 – 18) −27.3 (−68.6 – 37.5) 17 (9 – 22) 20 (16 – 22) 0.0 (−22.7 – 38.5) 0.244
Folate (ug/L) 24 (23 – 35) 23 (7.0 – 35) −0.4 (−67.8 – 34.2) 26 (23 – 38) 21 (10 – 24) −43.6 (−71.6 – 6.0) 0.443
Urine urea (mmol/L) 267 (139 – 396) 271 (213 – 313) 6.9 (−67.9 – 205.3) 155 (97 – 244) 244 (185 – 322) 45.1 (−19.5 – 258.3) 0.484
Urine creatinine (mmol/L) 11 (8 – 14) 9 (8 – 12) −20.0 (−46.3 – 13.1) 9 (5 – 13) 9 (7 – 10) 20.0 (−36.9 – 97.7) 0.334
Urine protein (g/mmol) 0.28 (0.18 – 0.63) 0.21 (0.17 – 0.39) −43.3 (−86.2 – -18.2) 0.20 (0.11 – 0.47) 0.19 (0.10 – 0.24) −41.7 (−61.5 – 81.8) 0.459
Physical activity/Energy expenditure
Physical activity score 17 (14 – 23)* 12 (11 – 13) −37 (−52 – -14) 14 (12 – 17)* 11 (10 – 18) −10 (−23 – 10) 0.037
Basal Metabolic Rate (BMR) 1273 (1205 – 1345) 1312 (1226 – 1481) 5.3 (3.2 – 12.3) 1357 (1244 – 1402) 1365 (1218 – 1429) −0.2 (−1.0 – 2.7) 0.014

*Significant difference between NS and Control group at baseline (p < 0.05); #Median (IQR) of the differences (% change) between baseline and 6 months. The percentage change was compared between the two arms, nutritional supplement and Control arm.

Evans et al.

Evans et al. Nutrition Journal 2013 12:111   doi:10.1186/1475-2891-12-111

Open Data