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High potency fish oil supplement improves omega-3 fatty acid status in healthy adults: an open-label study using a web-based, virtual platform

Jay K Udani1 and Barry W Ritz23*

Author Affiliations

1 Medicus Research, 28720 Roadside Drive, Suite 310, Agoura, CA 91301, USA

2 2Atrium Innovations Inc, 4 Hillman Drive, Suite 190, Chadds Ford, PA 19348, USA

3 3Nutrition Sciences Department, College of Nursing and Health Professions, Drexel University, 245 N. 15th Street, Philadelphia, PA 19102, USA

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Nutrition Journal 2013, 12:112  doi:10.1186/1475-2891-12-112

Published: 8 August 2013



The health benefits of omega-3 fatty acids from fish are well known, and fish oil supplements are used widely in a preventive manner to compensate the low intake in the general population. The aim of this open-label study was to determine if consumption of a high potency fish oil supplement could improve blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and impact SF-12 mental and physical health scores in healthy adults.


A novel virtual clinical research organization was used along with the HS-Omega-3 Index, a measure of EPA and DHA in red blood cell membranes expressed as a percentage of total fatty acids that has been shown to correlate with a reduction in cardiovascular and other risk factors. Briefly, adult subjects (mean age 44 years) were recruited from among U.S. health food store employees and supplemented with 1.1 g/d of omega-3 from fish oil (756 mg EPA, 228 mg DHA, Minami Nutrition® MorEPA® Platinum) for 120 days (n = 157).


Omega-3 status and mental health scores increased with supplementation (p < 0.001), while physical health scores remained unchanged.


The use of a virtual, web-based platform shows considerable potential for engaging in clinical research with normal, healthy subjects. A high potency fish oil supplement may further improve omega-3 status in a healthy population regularly consuming an omega-3 supplement.

Omega-3 index; Eicosapentaenoic acid; Docosahexaenoic acid; Fish oil; Open-label