Reasearch Awards nomination

Email updates

Keep up to date with the latest news and content from Nutrition Journal and BioMed Central.

Open Access Research

Development of a complex amino acid supplement, Fatigue Reviva™, for oral ingestion: initial evaluations of product concept and impact on symptoms of sub-health in a group of males

R Hugh Dunstan1*, Diane L Sparkes1, Tim K Roberts2, Marcus J Crompton1, Johan Gottfries3 and Benjamin J Dascombe4

Author Affiliations

1 School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia

2 The Tom Farrell Institute for the Environment, University of Newcastle, Callaghan, NSW 2308, Australia

3 Department of Chemistry and Molecular Biology, Gothenburg University, Gothenburg, Sweden

4 School of Environmental and Life Sciences, University of Newcastle, Ourimbah, NSW 2258, Australia

For all author emails, please log on.

Nutrition Journal 2013, 12:115  doi:10.1186/1475-2891-12-115

Published: 8 August 2013

Abstract

Background

A new dietary supplement, Fatigue Reviva™, has been recently developed to address issues related to amino acid depletion following illness or in conditions of sub-health where altered amino acid homeostasis has been associated with fatigue. Complex formulations of amino acids present significant challenges due to solubility and taste constraints. This initial study sets out to provide an initial appraisal of product palatability and to gather pilot evidence for efficacy.

Methods

Males reporting symptoms of sub-health were recruited on the basis of being free from any significant medical or psychological condition. Each participant took an amino acid based dietary supplement (Fatigue Reviva™) daily for 30 days. Comparisons were then made between pre- and post-supplement general health symptoms and urinary amino acid profiles.

Results

Seventeen men took part in the study. Following amino acid supplementation the total Chalder fatigue score improved significantly (mean ± SEM, 12.5 ± 0.9 versus 10.0 ± 1.0, P<0.03). When asked whether they thought that the supplement had improved their health, 65% of participants responded positively. A subgroup of participants reported gastrointestinal symptoms which were attributed to the supplement and which were believed to result from the component fructooligosaccharide. Analysis of urinary amino acids revealed significant alterations in the relative abundances of a number of amino acids after supplementation including an increase in valine, isoleucine and glutamic acid and reduced levels of glutamine and ornithine. Discriminant function analysis of the urinary amino acid data revealed significant differences between the pre- and post-supplement urine excretion profiles.

Conclusions

The results indicated that Fatigue Reviva™ was palatable and that 65% of the study group reported that they felt the product had improved their health. The product could provide an effective tool for the management of unexplained fatigue and symptoms of sub-health. Further product development may yield additional options for those patients susceptible to fructooligosaccharide.

Keywords:
Sub-health; Fatigue; Amino acid; Dietary supplement