Table 3

OR and 95% CI of hyperhomocysteinemia and hypercysteinemia by quartiles of different dietary protein intake
Hyperhomocysteinemiaa Hypercysteinemiaa
Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4
n 253 254 254 254 253 254 254 254
Total protein intake
Crude OR (95% CI)b 1 1.20(0.84-1.71) 1.30(0.91-1.85) 1.94(1.36-2.77)** 1 1.20(0.70-2.06) 1.60(0.96-2.68) 1.78(1.07-2.96)*
Adjusted OR (95% CI)c 1 1.30(0.89-1.91) 1.37(0.94-1.99) 2.13(1.45-3.12)** 1 1.16(0.66-2.04) 1.67(0.97-2.86) 1.73(1.03-2.92)*
Adjusted OR (95% CI)d 1 1.48(0.98-2.25) 1.57(1.02-2.41)* 2.63(1.70-4.07)** 1 1.14(0.64-2.03) 1.56(0.89-2.75) 1.69(1.02-2.87)*
Animal protein intake
Crude OR (95% CI)b 1 1.46(1.01-2.10)* 1.79(1.25-2.58)* 3.32(2.30-4.79)** 1 1.27(0.76-2.13) 1.34(0.80-2.24) 1.50(0.91-2.49)
Adjusted OR (95% CI)c 1 1.51(1.03-2.22)* 1.87(1.27-2.75)* 3.73(2.52-5.54)** 1 1.28(0.74-2.21) 1.45(0.84-2.51) 1.59(0.93-2.70)
Adjusted OR (95% CI)d 1 1.56(1.03-2.38)* 2.01(1.31-3.08)* 4.14(2.67-6.43)** 1 1.34(0.77-2.36) 1.51(0.85-2.68) 1.60(0.91-2.80)
Plant protein intake
Crude OR (95% CI)b 1 0.77(0.54-1.10) 0.51(0.35-0.72)** 0.46(0.32-0.66) ** 1 1.01(0.62-1.62) 0.91(0.55-1.48) 0.88(0.53-1.44)
Adjusted OR (95% CI)c 1 0.77(0.53-1.10) 0.54(0.37-0.79)* 0.47(0.32-0.68)** 1 1.11(0.66-1.86) 1.02(0.61-1.70) 0.90(0.53-1.51)
Adjusted OR (95% CI)d 1 0.76(0.51-1.13) 0.63(0.41-0.96)* 0.59(0.38-0.91)* 1 1.28(0.73-2.26) 1.12(0.64-1.93) 0.96(0.56-1.64)

aCut-off points are > 16 μmol/L for plasma homocysteine and > 300 μmol/L for plasma cysteine.

bValues are OR (95% CI) from logistic regression.

cValues are OR (95% CI) from logistic regression adjusted for age, sex, total energy intake, total fat intake, and BMI.

dValues are OR (95% CI) from logistic regression adjusted for age, sex, total energy intake, total fat intake, BMI, smoking, alcohol use, tea use, hypertension, diabetes, folate, PLP, vitamin B12, HDL, LDL, and creatinine. Asterisks indicate difference from lowest quartiles of different dietary protein intake. *P < 0.05, **P < 0.001.

Xiao et al.

Xiao et al. Nutrition Journal 2013 12:144   doi:10.1186/1475-2891-12-144

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