Table 1

Main characteristics of randomized controlled trials included in the meta-analysis
Study No. of patients (Antioxidant/Control) Patient characteristics Antioxidant supplement Intervention Study design Jadad score
Antioxidant Control
Wollschläger et al. [21] 40 (20/20) Adult patients undergoing ERCP Selenite Selenite, intravenously, 1 mg bolus/2 x 1 mg infusion, l d before ERCP Control, no prophylaxis Randomized, controlled 2
Budzyńska et al. [22] 200 (99/101) Adult consecutive patients undergoing elective ERCP Allopurinol Allopurinol, orally, 200 mg, 15 h and 3 h before ERCP Placebo, orally, 200 mg, 15 h and 3 h before ERCP Randomized, placebo-controlled 3
Lavy et al. [23] 321 (141/180) Adult consecutive patients undergoing ERCP β-carotene β-carotene, orally, 2 g, 12 h before ERCP Placebo, orally, 2 g, 12 h before ERCP Randomized, double-blind, placebo-controlled 5
Katsinelos et al. [24] 249 (124/125) Adult consecutive patients undergoing diagnostic or therapeutic ERCP NAC NAC, intravenously, 70 mg/kg 2 h before, and 35 mg/kg at 4 h intervals for 24 h after ERCP Placebo (0.9% saline solution), intravenously, 70 mg/kg 2 h before, and 35 mg/kg at 4 h intervals for 24 h after ERCP Randomized, double-blind, placebo-controlled 5
Katsinelos et al. [25] 243 (125/118) Adult consecutive patients undergoing diagnostic or therapeutic ERCP Allopurinol Allopurinol, orally, 600 mg, 15 h and 3 h before ERCP Placebo, orally, 600 mg, 15 h and 3 h before ERCP Randomized, double-blind, placebo-controlled 5
Mosler et al. [26] 701 (355/346) Adult patients undergoing diagnostic or therapeutic ERCP Allopurinol Allopurinol, orally, 4 h (600 mg) and 1 h (300 mg) before ERCP Placebo (similar pill without the active drug), orally, 4 h (600 mg) and 1 h (300 mg) before ERCP Randomized, double-blind, placebo-controlled 5
Milewski et al. [27] 106 (55/51) Adult consecutive patients undergoing ERCP NAC NAC, two 600 mg given orally 24 h and 12 h before ERCP and 600 mg given intravenously for 2 d after ERCP Placebo (isotonic saline), intravenously, twice a day for 2 d after ERCP Randomized, placebo-controlled 2
Kapetanos et al. [28] 320 (158/162) Adult patients undergoing ERCP Pentoxifylline Pentoxifylline, orally, 400 mg, beginning the day before ERCP (2 and 10 PM) until the night after ERCP (6 AM and 2 and 10PM) No intervention Randomized, controlled 3
Romagnuolo et al. [29] 586 (293/293) Adult patients undergoing ERCP Allopurinol Allopurinol, orally, 300 mg, 1 h before ERCP Placebo, orally, 300 mg, 1 h before ERCP Randomized, double-blind, placebo-controlled 5
Martinez et al. [30] 170 (85/85) Adult patients undergoing ERCP Allopurinol Allopurinol, orally, 300 mg, 15 h and 3 h before ERCP Placebo, orally, 300 mg, 15 h and 3 h before ERCP Randomized, placebo-controlled 3
Abbasinazari et al. [31] 74 (29/45) Adult patients undergoing ERCP Allopurinol Allopurinol, orally, 300 mg, 15 h and 3 h before ERCP Placebo, orally, 300 mg, 15 h and 3 h before ERCP Randomized, double-blind, placebo-controlled 3

ERCP = endoscopic retrograde cholangiopancreatography, NAC = N-acetylcysteine.

Gu et al.

Gu et al. Nutrition Journal 2013 12:23   doi:10.1186/1475-2891-12-23

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