Figure 4.

The modified canonical pathways according to scores for the Western dietary pattern. Legend: Gene expression differences (≥ ± 1.2 fold change) in canonical pathways comparing high and low scores for the Western dietary pattern (A) For the men (B) For the women. P-values for Functional Analysis of dataset by IPA (Fisher’s Exact Test) are presented. % of genes significantly up-regulated and down-regulated in each canonical pathway are presented (number of genes differently expressed/number of genes in the pathways*100). (A) Endothelin-1 Signaling: P = 0.01, 12 genes significantly different; PTEN Signaling: P = 0.01, 10 genes significantly different; iCOS-iCOSL Signaling in T Helper Cells: P = 0.008, 9 genes significantly different; Hypoxia Signaling in the Cardiovascular System: P = 0.006, 7 genes significantly different; Xenobiotic Metabolism Signaling: P = 0.005, 18 genes significantly different; NGF Signaling: P = 0.004, 10 genes significantly different; Neurotrophin/TRK Signaling: P = 0.00001, 11 genes significantly different. (B) IL-8 Signaling: P = 0.04, 15 genes significantly different; FXR/RXR Activation: P = 0.05, 9 genes significantly different; Atherosclerosis Signaling: P = 0.02, 12 genes significantly different; Role of Cytokines in Mediating Communication between Immune Cells: P = 0.02, 7 genes significantly different; Toll-like Receptor Signaling: P = 0.01, 7 genes significantly different; Role of NFAT in Regulation of the Immune Response: P = 0.01, 16 genes significantly different; Bladder Cancer Signaling: P = 0.002, 12 genes significantly different; Nf-κB Signaling: P = 0.002, 18 genes significantly different.