Table 6

Chronic changes in methylxanthine concentrations after daily consumption of 20-g chocolate
Low-flavanol High-flavanol P value of change between treatments
Chocolate Chocolate
(n = 20) (n = 22)
Theobromine (μg/mL)
Baseline 0.35 ± 0.37 0.45 ± 0.43 -
Week 6 1.44 ± 0.73 1.82 ± 0.76 0.34
Week 12 1.30 ± 0.69 1.87 ± 0.85 0.03
P value (Week 6 vs. Baseline) <0.0001 <0.0001
P value (Week 12 vs. Baseline) <0.0001 <0.0001
Theophylline (μg/mL)
Baseline 0.07 ± 0.11 0.13 ± 0.18 -
Week 6 0.24 ± 0.24 0.27 ± 0.29 0.66
Week 12 0.17 ± 0.17 0.27 ± 0.20 0.49
P value (Week 6 vs. Baseline) 0.0001 0.045
P value (Week 12 vs. Baseline) 0.0003 0.0076
Caffeine (μg/mL)
Baseline 0.29 ± 0.46 0.58 ± 0.82 -
Week 6 1.12 ± 1.27 1.30 ± 2.08 0.78
Week 12 0.82 ± 1.15 1.56 ± 2.05 0.34
P value (Week 6 vs. Baseline) 0.004 0.12
P value (Week 12 vs. Baseline) 0.02 0.03

Values are means ± SD.

Mogollon et al.

Mogollon et al. Nutrition Journal 2013 12:41   doi:10.1186/1475-2891-12-41

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