Table 1

Pharmacokinetic parameters of curcuminoid concentrations Area Under the Curve (AUC), cmax, tmax, and relative absorption for each formulation
Curcuminoid Formulation AUC0-12 (ng/mL•hr) Cmax (ng/mL) tmax (h) Relative Absorption (F)
Curcumin CS 10.8 ± 1.7x 2.3 ± 0.3 7.4 ± 1.0^ 1.0
CTR 5.8 ± 0.1 0.5 ± 0.0 3.2 ± 1.0 2.6
CP 28.7 ± 2.6+ 2.8 ± 0.3 1.7 ± 1.0 12.7+
CHC 307.6 ± 44.6# 27.3 ± 6.4# 1.4 ± 0.5 136.3#
Demethoxycurcumin CS 18.4 ± 2.3 1.7 ± 0.2x 1.2 ± 0.1 1.0
CTR 2.2 ± 0.5 0.2 ± 0.1 8.1 ± 0.2^& 0.6
CP 28.0 ± 3.3x 5.0 ± 0.7+ 1.0 ± 0.1 7.3+
CHC 54.5 ± 8.1+ 5.4 ± 1.1+ 11.9 ± 0.1^& 14.2#
Bisdemethoxycurcumin CS 9.3 ± 0.8x 1.1 ± 0.1x 1.3 ± 1.1 1.0
CTR 2.6 ± 0.4 0.3 ± 0.1 11.9 ± 0.7^& 1.3
CP 6.7 ± 0.3x 0.8 ± 0.1x 1.3 ± 0.2 3.5+
CHC 10.2 ± 1.3x 1.4 ± 0.2x 11.9 ± 1.2^& 5.3#
Tetrahydrocurcumin CS 1.1 ± 0.1 0.1 ± 0.0 8.1 ± 1.1 1.0
CTR 0.3 ± 0.1 0.0 ± 0.0 8.2 ± 1.0 1.3
CP 1.9 ± 0.2 0.2 ± 0.0x 8.0 ± 1.2 8.3+
CHC 7.7 ± 0.6# 0.7 ± 0.0# 8.0 ± 0.8 33.5#
Total Curcuminoids CS 39.6 ± 1.5x 5.2 ± 0.2x 9.5 ± 0.2x^ 1.0
CTR 10.9 ± 0.4 1.1 ± 0.1 1.8 ± 0.7 1.3
CP 65.3 ± 2.3+ 8.7 ± 0.4+ 1.7 ± 0.4 7.9+
CHC 380.0 ± 23.9# 34.9 ± 3.3# 1.7 ± 0.4 45.9#

Data expressed as geometric (AUC, cmax) or arithmetic (tmax) mean ± standard errors. #significantly different (p < 0.05) compared to CS, CTR, and CP. +significant different (p < 0.05) compared to CS and CTR. xsignificantly different (p < 0.05) compared to CTR. ^significantly different (p < 0.05) compared to CP. &significantly different (p < 0.05) compared to CS.

Jäger et al.

Jäger et al. Nutrition Journal 2014 13:11   doi:10.1186/1475-2891-13-11

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