Table 5

Safety assessments in participants taking either rice bran fermented with Lentinus edodes (RBEP) or placebo1
RBEP (n = 40) Placebo (n = 37)
Week 0 Week 4 Week 8 Week 0 Week 4 Week 8
Red blood cell count (× 1012/L) 4.33 ± 0.43 4.47 ± 0.50 4.47 ± 0.44 4.38 ± 0.43 4.58 ± 0.41 4.56 ± 0.42
White blood cell count (× 109/L) 5.96 ± 1.14 5.82 ± 1.21 5.52 ± 1.12 5.85 ± 1.40 5.79 ± 1.16 5.85 ± 1.20
Hemoglobin (g/L) 140.10 ± 13.10 138.70 ± 14.00 139.60 ± 13.30 140.10 ± 12.60 140.50 ± 12.00 140.30 ± 12.70
Hematocrit (%) 41.45 ± 4.13 42.38 ± 4.48 42.09 ± 3.85 41.46 ± 3.90 42.76 ± 3.62 42.34 ± 3.99
Platelet count (× 109/L) 236.13 ± 39.602 242.18 ± 46.44 243.35 ± 45.91 259.11 ± 61.152 266.19 ± 55.50 267.97 ± 46.08
Segmented neutrophils (%) 54.75 ± 7.61 53.25 ± 5.79 53.30 ± 7.13 54.65 ± 8.47 54.91 ± 5.77 54.97 ± 5.95
Lymphocytes (%) 34.83 ± 7.29 37.60 ± 5.95 36.80 ± 6.65 36.27 ± 7.25 35.78 ± 5.80 35.05 ± 5.52
Monocytes (%) 6.63 ± 1.51 5.90 ± 1.22 6.53 ± 1.45 6.19 ± 1.29 5.84 ± 1.48 6.30 ± 1.61
Eosinophils (%) 2.78 ± 1.21 2.38 ± 0.90 2.38 ± 1.17 2.51 ± 1.26 2.32 ± 1.08 2.73 ± 1.35
Basophils (%) 1.03 ± 0.48 0.88 ± 0.52 1.00 ± 0.55 0.84 ± 0.55 0.97 ± 0.44 0.95 ± 0.57
AST (U/I) 21.25 ± 6.41 21.88 ± 7.77 23.58 ± 9.67 25.24 ± 11.25 24.16 ± 7.30 25.65 ± 10.63
ALT (U/I) 17.20 ± 14.66 17.50 ± 22.40 25.53 ± 27.40 22.51 ± 16.31 21.24 ± 13.41 27.57 ± 19.08
Total protein (g/L) 72.20 ± 4.00 72.60 ± 5.00 73.50 ± 3.90 73.20 ± 3.80 72.50 ± 5.30 74.20 ± 3.70
Glucose (mmol/L) 4.43 ± 0.37 4.31 ± 0.30 4.86 ± 0.45 4.55 ± 0.37 4.44 ± 0.31 4.97 ± 0.38
Total cholesterol (mmol/L) 4.74 ± 0.81 4.64 ± 0.81 5.00 ± 0.84 4.87 ± 0.90 4.81 ± 0.90 5.22 ± 0.88
Blood urea nitrogen (mmol/L) 4.33 ± 0.81 4.51 ± 1.16 4.84 ± 1.12 4.45 ± 1.07 4.59 ± 1.21 5.03 ± 1.10
Creatinine (μmol/L) 60.25 ± 10.68 68.63 ± 15.25 61.01 ± 10.68 61.77 ± 14.49 67.11 ± 14.21 62.53 ± 14.00
Uric acid (μmol/L) 294.43 ± 63.642 281.34 ± 55.91 311.08 ± 73.16 318.81 ± 74.35 293.24 ± 60.07 342.60 ± 77.32
Calcium (mmol/L) 2.24 ± 0.08 2.27 ± 0.06 2.25 ± 0.06 2.23 ± 0.08 2.26 ± 0.07 2.24 ± 0.06
Phosphorus (mmol/L) 1.14 ± 0.14 1.24 ± 0.10 1.22 ± 0.09 1.15 ± 0.12 1.21 ± 0.12 1.22 ± 0.11
SBP (mmHg) 116.43 ± 15.20 116.03 ± 11.76 120.15 ± 13.55 118.87 ± 11.73 117.46 ± 12.05 121.32 ± 13.54
DBP (mmHg) 71.73 ± 9.73 71.98 ± 9.74 74.85 ± 9.73 71.11 ± 8.97 73.65 ± 9.39 75.59 ± 10.39
Pulse rate (beats/min) 76.48 ± 9.93 75.53 ± 10.89 75.50 ± 10.61 73.22 ± 11.01 75.54 ± 10.81 74.68 ± 10.24
Body temperature (°C) 36.24 ± 0.38 35.95 ± 0.35 35.97 ± 0.44 36.29 ± 0.41 36.15 ± 0.44 36.04 ± 0.42

1Values shown represent means ± standard deviation. AST, Aspartate aminotransferase; AT, Alanine aminotransferase; SBP, Systolic blood pressure; DBP, Diastolic blood pressure.

2P-values < 0.05 for differences between the RBEP and placebo groups at week 0 were determined using the independent t-test.

Choi et al.

Choi et al. Nutrition Journal 2014 13:35   doi:10.1186/1475-2891-13-35

Open Data