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Dietary ascorbic acid and subsequent change in body weight and waist circumference: associations may depend on genetic predisposition to obesity - a prospective study of three independent cohorts

Sofus C Larsen1*, Lars Ängquist1, Tarunveer Singh Ahluwalia23, Tea Skaaby4, Nina Roswall5, Anne Tjønneland5, Jytte Halkjær5, Kim Overvad67, Oluf Pedersen2, Torben Hansen2, Allan Linneberg4, Lise Lotte N Husemoen4, Ulla Toft4, Berit L Heitmann1489 and Thorkild IA Sørensen12

Author Affiliations

1 Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, the Capital Region, Nordre Fasanvej 57, Hovedvejen, entrance 5, ground floor, 2000, Frederiksberg Copenhagen, Denmark

2 The Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

3 Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

4 Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark

5 Danish Cancer Society Research Center, Copenhagen, Denmark

6 Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

7 Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark

8 The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

9 The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, The University of Sydney, Sydney, Australia

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Nutrition Journal 2014, 13:43  doi:10.1186/1475-2891-13-43

Published: 3 May 2014

Additional files

Additional file 1: Table S1:

Information on the 50 SNP's included in this study. The individual SNPs are sorted by refSNP (rs) number and grouped according to their associated trait. Table S2. Baseline body weight (kg) and waist circumference (cm) pr. 100 mg/day higher ascorbic acid intake in the three cohorts. Results are presented both from the crude and the adjusted models. Table S3. SNP × ascorbic acid interaction in relation to annual change in body weight (kg/year) per 100 mg/day higher ascorbic acid intake in MONICA, DCH and INTER99 (β and p-value). The results are sorted by refSNP (rs) number and grouped according to their associated trait. Table S4. SNP × ascorbic acid interaction in relation to annual change in waist circumference (cm/year) per 100 mg/day higher ascorbic acid intake in MONICA, DCH and INTER99 (β and p-value). The results are sorted by refSNP (rs) number and grouped according to their associated trait. Figure S1. Annual change in body weight (kg/year) per 100 mg/day higher ascorbic acid intake in tertiles of the BMI associated SNP score. Figure S2. Interaction between genetic predisposition scores and dietary ascorbic acid in relation to change in waist circumference adjusted for concurrent change in body weight. Figure S3. Annual change in waist circumference (cm/year) per 100 mg/day higher ascorbic acid intake in tertiles of the WHR associated SNP score.

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