Interaction between genetic predisposition scores and dietary ascorbic acid in relation to change in body weight. Abbreviations: BMI score, sum of body mass index associated risk-alleles; WC score, sum of waist circumference associated risk-alleles; WHR score, sum of waist-hip ratio associated risk-alleles; Complete score, sum of SNP associated to all three phenotypes. Results presented as annual weight change (kg/year) effect-modification for each additional risk-allele per 100 mg/day higher ascorbic acid intake. The study-specific SNP-score × ascorbic acid interactions were calculated using linear regression and corresponding meta-analysis results were derived using a fixed effect approach, where the effect-estimates where weighted by the inverses of their variances (% weight). The results were adjusted for baseline measure of body weight, height, sex, age, smoking status, alcohol consumption, physical activity, education and menopausal status for women.
Larsen et al. Nutrition Journal 2014 13:43 doi:10.1186/1475-2891-13-43