Table 1

Ascorbic acid intake, anthropometrics, SNP-scores and covariates in MONICA, DCH and INTER99
MONICA DCH INTER99
N 1,329 2,167 4,073
Basic variables
Ascorbic acid (mg/day) 70 (23 to 199) 93 (43 to 207) 66 (25 to 156)
Baseline age (years) 50.5 (30.6 to 61.1) 53.0 (50.0 to 58.0) 45.1 (34.7 to 59.8)
Sex (% women) 51.6 49.4 51.4
Height (cm) 169 (156 to 184) 171 (158 to 186) 172 (158 to 188)
BW (kg)
Baseline 69.0 (52.0 to 93.0) 77.1 (56.8 to 104.4) 75.5 (55 to 104)
Follow-up 70.0 (51.6 to 94.7) 82.0 (58.0 to 110.0) 76.5 (55.6 to 105.0)
∆BW 0.22 (−1.04 to 1.61) 1.01 (−1.05 to 2.39) 0.20 (−1.41 to 1.75)
WC (cm)1
Baseline - 90 (70 to 112) 85 (67 to 107)
Follow-up - 98 (76 to 121) 88 (69 to 110)
∆WC - 1.37 (−0.78 to 4.44) 0.55 (−1.27 to 2.46)
SNP-based variables2
SNP-score (BMI) 29 (23 to 35) 28 (23 to 35) 29 (23 to 34)
SNP-score (WC) 3 (1 to 6) 3 (1 to 6) 3 (1 to 6)
SNP-score (WHR) 14 (10 to 18) 14 (10 to 18) 14 (10 to 18)
SNP-score (complete) 44 (37 to 52) 44 (37 to 51) 44 (36 to 51)
Adjustment variables
Smoking, % Never smokers 27 41.4 40.1
Education, % ≤ Primary school 35.7 30.1 26.2
Physical activity, % most sedentary group 21.4 9.5 11.5
Menopausal status, % postmenopausal 42.4 55.6 27.5
Total energy intake excl. alcohol, (MJ/day) 8.5 (4.8 to 13.9) 8.2 (4.9 to 13.4) 9.0 (4.9 to 15.1)
Alcohol (MJ/day) 0.4 (0 to 1.8) 0.4 (0 to 1.9) 0.3 (0 to 1.5)

Abbreviations: BW body weight, WC waist circumference, ∆BW annual weight change, ∆WC annual WC change.

1DCH: n = 2,165 on baseline WC, n = 2,130 on follow-up WC and n = 2,128 on ∆WC. INTER99: n = 4,067 on baseline WC, n = 3,540 on follow-up WC and n = 3,536 on ∆WC.

2Sum of BMI, WC or WHR associated risk-alleles. In MONICA information was available in n = 989 on BMI SNP-score, n = 1,250 on WC SNP-score, n = 1,185 on WHR SNP-score and n = 878 on complete SNP-score. In DCH n = 1,438 on BMI SNP-score, n = 1,805 on WC SNP-score, n = 1,624 on WHR SNP-score and n = 1,247 on complete SNP-score. In INTER99 n = 2,511 on BMI SNP-score, n = 3,381 on WC SNP-score, n = 3,264 on WHR SNP-score, n = 2,082 on complete score.

Results presented as median (5–95 percentiles) unless otherwise stated.

Larsen et al.

Larsen et al. Nutrition Journal 2014 13:43   doi:10.1186/1475-2891-13-43

Open Data