Table 5

Bone metabolism markers and bone-related hormones in blood and urine after intervention with either tricalcium phosphate, vitamin D3 or both
Parameter Supplements Placebo Interventions
4 weeks 8 weeks
Plasma 1,25-(OH)2D [pmol/l] CaPt 102.9a (24.7) 93.3b (24.7) 76.3c (24.5)
Vitamin D3t 97.9 (27.5) 108.3 (23.9) 99.2 (38.1)
CaP+vitamin D3t 92.2b (31.0) 100.4a (31.1) 86.0b (23.1)
Plasma osteocalcin [ng/ml] CaP 20.3 (6.5) 20.4 (6.5) 20.9 (7.2)
Vitamin D3 21.8 (7.2) 23.4 (8.2) 20.7 (8.8)
CaP+vitamin D3 20.1 (7.0) 20.2 (6.4) 19.9 (7.6)
Plasma alkaline phosphatase CaP 9.6a (3.9) 10.7b (3.9) 9.3a (3.7)
Vitamin D3 9.1a (3.5) 10.3b (3.6) 9.0a (3.6)
CaP+vitamin D3 9.8a (3.4) 11.3b (3.9) 9.5a (3.1)
Serum PTH [μg/l] CaP 56.6 (12.2) 74.4 (35.8) 71.9 (25.1)
Vitamin D3 65.0 (24.7) 71.2 (29.2) 66.5 (21.0)
CaP+vitamin D3 62.0 (20.1) 63.3 (17.8) 60.6 (19.8)
Serum CTX [ng/ml] CaP 0.3 (0.1) 0.2 (0.1) 0.3 (0.2)
Vitamin D3 0.3 (0.2) 0.3 (0.2) 0.3 (0.1)
CaP+vitamin D3 0.3 (0.1) 0.2 (0.1) 0.2 (0.1)
Serum P1NP [ng/ml] CaP 44.5 (19.1) 42.5 (16.5) 44.2 (19.7)
Vitamin D3 48.8 (18.9) 44.4 (20.7) 50.9 (24.7)
CaP+vitamin D3 41.4 (17.6) 36.3 (19.7) 40.4 (15.9)
Urine DPD [nmol/l] CaP 29.2 (14.9) 31.6 (20.0) 27.0 (14.5)
Vitamin D3 25.3 (13.7) 22.8 (11.5) 25.5 (9.8)
CaP+vitamin D3 23.7 (9.0) 25.8 (16.0) 28.1 (15.2)
Urine CTX [mg/l] CaP 1.0 (0.6) 1.1 (1.1) 0.7 (0.5)
Vitamin D3 0.9 (0.7) 0.8 (0.6) 1.1 (0.6)
CaP+vitamin D3 0.9 (0.7) 0.9 (0.7) 1.2 (1.1)

n = 55; data are expressed as mean (standard deviation); CaP: tricalcium phosphate; 1,25-(OH)2D: 1alpha,25-dihydroxyvitamin D; 25-(OH)D: 25-hydroxyvitamin D; PTH: parathormone; CTX: cross-linked C-terminal telopeptide of type I collagen; P1NP: N-terminal propeptide of type I procollagen; DPD: desoxypyridinoline; a b mean values within a row with dissimilar superscript letters are significantly different (p ≤ 0.05); results without superscripts in a row/column have no significant differences; effect of time was tested using general linear model with repeated measurements (with pairwise comparisons based on Fishers-LSD test); effect of supplementation was tested using univariate analysis of variance followed by Student-Newman-Keuls post hoc test; t for statistical analysis the data were log10 transformed, because of variance heterogeneity.

Trautvetter et al.

Trautvetter et al. Nutrition Journal 2014 13:6   doi:10.1186/1475-2891-13-6

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