Open Access Open Badges Review

Ingested hyaluronan moisturizes dry skin

Chinatsu Kawada1, Takushi Yoshida1, Hideto Yoshida1, Ryosuke Matsuoka1*, Wakako Sakamoto1, Wataru Odanaka1, Toshihide Sato1, Takeshi Yamasaki1, Tomoyuki Kanemitsu1, Yasunobu Masuda1 and Osamu Urushibata2

Author Affiliations

1 R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan

2 Department of Dermatology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, Japan

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Nutrition Journal 2014, 13:70  doi:10.1186/1475-2891-13-70

Published: 11 July 2014


Hyaluronan (HA) is present in many tissues of the body and is essential to maintain moistness in the skin tissues, which contain approximately half the body’s HA mass. Due to its viscosity and moisturizing effect, HA is widely distributed as a medicine, cosmetic, food, and, recently marketed in Japan as a popular dietary supplement to promote skin moisture. In a randomized, double-blind, placebo-controlled clinical study it was found that ingested HA increased skin moisture and improved treatment outcomes for patients with dry skin. HA is also reported to be absorbed by the body distributed, in part, to the skin. Ingested HA contributes to the increased synthesis of HA and promotes cell proliferation in fibroblasts. These effects show that ingestion of HA moisturizes the skin and is expected to improve the quality of life for people who suffer from dry skin. This review examines the moisturizing effects of dry skin by ingested HA and summarizes the series of mechanisms from absorption to pharmacological action.

Hyaluronan; Hyaluronic acid; Ingestion; Dry skin; Moisturizing