Table 1

Summary on the skin improving effects of ingested hyaluronan
Test method Test design Substance Subjects Results References
Oral consumption of HA at 240 mg daily for 6 weeks Randomized, double-blind, placebo-controlled trial HA (M.W.: 80 K) 22 patients with dry skin (in Japan) Improved dry skin on the face and whole body Kajimoto, O. et al. (2001) [15]
Significant increase of skin moisture
Oral consumption of HA at 120 mg daily for 4 weeks Randomized, double-blind, placebo-controlled trial HA (M.W.: 80 K) 35 patients with dry skin (in Japan) Significant increase of skin moisture Sato, T. et al. (2002) [16]
Oral consumption of HA at 120 mg daily for 6 weeks Randomized, double-blind, placebo-controlled trial HA (M.W.: 80 K) 39 female patients with dry skin (in Japan) Significant increase of skin moisture Sato, T. et al. (2007) [17]
Oral consumption of HA at 120 mg daily for 6 weeks Randomized, double-blind, placebo-controlled trial HA (M.W.: 30 K) 42 female patients with dry skin (in Japan) Significant increase of skin moisture Yoshida, T. et al. (2009) [18]
Oral consumption of HA at 37.52 mg daily for 30 days Randomized, single-blind, placebo-controlled trial Mixture containing HA (M.W. of HA: 2,500) 107 healthy subjects (in China) Significant increase in skin moisture Terashita, T. et al. (2011) [19]
Significant increase in skin pH
Oral consumption of HA at 100 mg daily for 12 weeks Prospective open-label trial Mixture containing HA(M.W.: unknown) 26 healthy female subjects (Caucasian, African-American, Hispanic, and others) Improved aging symptoms on the face Schwartz, S. R. et al. (2012) [20]

Kawada et al.

Kawada et al. Nutrition Journal 2014 13:70   doi:10.1186/1475-2891-13-70

Open Data