Open Access Open Badges Research

Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation

Daniéla Oliveira Magro1*, Lais Mariana R de Oliveira2, Isabela Bernasconi2, Marilia de Souza Ruela2, Laura Credidio2, Irene K Barcelos2, Raquel F Leal1, Maria de Lourdes Stesuko Ayrizono1, João José Fagundes1, Leandro de B Teixeira3, Arthur C Ouwehand3 and Claudio S R Coy1

Author Affiliations

1 Department of Surgery, Faculty of Medical Sciences, Campinas State University, Campinas, Brazil

2 GASTROCENTRO, Campinas State University, Campinas, Brazil

3 DuPont Nutrition and Health, Campinas, Brazil

For all author emails, please log on.

Nutrition Journal 2014, 13:75  doi:10.1186/1475-2891-13-75

Published: 24 July 2014



Constipation is a frequent complaint and the combination of a prebiotic and probiotics could have a potentially synergic effect on the intestinal transit. The present study therefore aims to investigate the combination of polydextrose (Litesse®), L. acidophilus NCFM® and B. lactis HN019 in a yogurt on intestinal transit in subjects who suffer from constipation.


Patients with constipation were randomly divided into two groups, Control Group (CG) and Treatment Group (TG), and had to eat 180 ml of unflavored yogurt every morning for 14 days. Those in the CG received only yogurt, while the TG received yogurt containing polydextrose, L. acidophilus NCFM® (ATCC 700396) and B. lactis HN019 (AGAL NM97/09513).


Favourable clinical response was assessed since Agachan score had a significant reduction at the end of the study in both groups and tended to be better in the TG. The subjects in the treatment group also had a shorter transit time at the end of the intervention compared to the control group (p = 0.01).


The product containing yogurt with polydextrose, B. lactis HN019 and L. acidophilus NCFM® significantly shortened colonic transit time after two weeks in the TG compared to CG and may be an option for treatment of constipation.

Chronic constipation; Lactobacillus acidophilus NCFM; Bifidobacterium lactis HN019