Table 1 |
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|
Breast Cancer and Omega 3:6 Ratio. |
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| Reference |
# of cases w/ breast cancer |
# of controls |
Post / pre Menopausal |
Measure of n-3 / n-6 fat |
Outcome |
Odds ratio (95% Confidence Interval) |
|
|
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| [183] |
565 |
554 (population and hospital) |
Pre & post |
Diet FFQ |
↑N3/N6 ratio in premenopausal women = Non-signif. ↓Breast cancer risk |
0.59 (0.29–1.19) |
| In study site with population controls, find ↑N3/N6 ratio = Signif ↓Breast Cancer
risk |
0.50 (0.27, 0.95) |
|||||
| [184] |
EURAMIC study |
Nested case-control study in population study |
Post |
Adipose tissue |
4 out of 5 centers showed ↑N3/N6 ratio = ↓Breast Cancer risk |
0.65 (p for trend = 0.55) |
| [185] |
241 |
88 w/ benign breast disease |
Both |
Adipose tissue |
↑DHA = ↓Breast cancer |
0.31 (0.13–0.75) |
| ↑Ratio of long chain N-3:N-6 fat = ↓Breast cancer |
0.33 (0.17–0.66) |
|||||
| [186] |
73 |
74 w/ macromastia |
? |
Adipose tissue |
N-6 fat content signif. higher in cases |
P = 0.02 |
| For given level of N-6 fat, EPA and DHA had a protective effect |
P = 0.06 |
|||||
| [187] |
71 (within ORDET study) |
142 (nested case control) |
Post |
RBC membranes |
↑DHA = ↓Breast cancer |
0.44 (0.21–0.92) |
| [67] |
380 |
397 |
Post |
Adipose tissue |
No associations between N-3:N-6 ratio and breast cancer |
|
| [188] |
314 (within Singapore Chinese Health study) |
Diet, FFQ |
↑Intake of N-3 fat from fish / shellfish = ↓Breast cancer, for all 3 highest quartiles |
0.74 (0.58–0.94) |
||
| Among women in lowest quartile of N-3 fat intake, ↑N-6 fat intake = ↓Breast cancer |
1.87 (1.06–3.27) |
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|
|
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|
Donaldson Nutrition Journal 2004 3:19 doi:10.1186/1475-2891-3-19 |
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