Table 1

Breast Cancer and Omega 3:6 Ratio.

Reference

# of cases w/ breast cancer

# of controls

Post / pre Menopausal

Measure of n-3 / n-6 fat

Outcome

Odds ratio (95% Confidence Interval)


[183]

565

554 (population and hospital)

Pre & post

Diet FFQ

↑N3/N6 ratio in premenopausal women = Non-signif. ↓Breast cancer risk

0.59 (0.29–1.19)

In study site with population controls, find ↑N3/N6 ratio = Signif ↓Breast Cancer risk

0.50 (0.27, 0.95)

[184]

EURAMIC study

Nested case-control study in population study

Post

Adipose tissue

4 out of 5 centers showed ↑N3/N6 ratio = ↓Breast Cancer risk

0.65 (p for trend = 0.55)

[185]

241

88 w/ benign breast disease

Both

Adipose tissue

↑DHA = ↓Breast cancer

0.31 (0.13–0.75)

↑Ratio of long chain N-3:N-6 fat = ↓Breast cancer

0.33 (0.17–0.66)

[186]

73

74 w/ macromastia

?

Adipose tissue

N-6 fat content signif. higher in cases

P = 0.02

For given level of N-6 fat, EPA and DHA had a protective effect

P = 0.06

[187]

71 (within ORDET study)

142 (nested case control)

Post

RBC membranes

↑DHA = ↓Breast cancer

0.44 (0.21–0.92)

[67]

380

397

Post

Adipose tissue

No associations between N-3:N-6 ratio and breast cancer

[188]

314 (within Singapore Chinese Health study)

Diet, FFQ

↑Intake of N-3 fat from fish / shellfish = ↓Breast cancer, for all 3 highest quartiles

0.74 (0.58–0.94)

Among women in lowest quartile of N-3 fat intake, ↑N-6 fat intake = ↓Breast cancer

1.87 (1.06–3.27)


Donaldson Nutrition Journal 2004 3:19   doi:10.1186/1475-2891-3-19

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