Table 2

Prospective Nested Case Control Studies of Selenium and Prostate Cancer.

Reference

Study

# Cases

# Controls

Outcomes

Comment


[189]

Physicians Health Study

586

577

↑Se = ↓risk of advance prostate cancer (OR = 0.52, 95% CI = 0.28–0.98)

Result only in men with PSA ≥ 4 ng/mL

[190]

Netherlands Cohort Study

540

1,211

↑Se = ↓risk prostate cancer (OR for quintiles of Se = 1.0, 1.05, 0.69, 0.75, 0.69; 95% CI = 0.48–0.99)

Results greatest in ex-smokers

[191]

Baltimore Longitudinal Study of Aging

52

96

↑Se = ↓risk prostate cancer (OR for quartiles of Se = 1.0, 0.15, 0.21, 0.24

[192]

Washington County, Maryland

117

233

Top 4/5 of Se had reduction in prostate cancer risk; statistically significant result for Se only when γtocopherol levels were high

Men in top quintile of serum γtocopherol had 5-fold reduced risk of prostate cancer compared to lowest quintile

[193]

Health Professional Follow-up Study

181

181

↑Se = ↓risk of advanced prostate cancer

Adjusted OR = 0.35 (95% CI = 0.16–0.78)

[194]

Prospective study

↑Se = ↓risk of gastrointestinal and prostate cancer

Results not statistically significant


Donaldson Nutrition Journal 2004 3:19   doi:10.1186/1475-2891-3-19

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