|
Genes and polymorphisms tested in the nutrigenetic patient group. |
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| Gene |
Gene symbol |
Polymorphism |
% homozygote wild type |
% heterozygote |
% homozygote variant |
HWE p < |
|
|
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| Angiotensin I converting enzyme |
ACE |
INS/DEL |
14.6% |
48.8% |
36.6% |
0.99 |
| Apolipoprotein C-III |
APOC3 |
3175C>G |
73.3% |
20.0% |
6.7% |
0.17 |
| Cystathionine-beta-synthase |
CBS |
699C>T |
53.5% |
41.9% |
4.7% |
0.81 |
| Cholesteryl ester transfer protein |
CETP |
279G>A |
48.8% |
39.5% |
11.6% |
0.86 |
| Collagen, type I, alpha 1 |
COL1A1 |
G Sp1 T |
58.1% |
34.9% |
7.0% |
0.94 |
| Glutathione S-transferase M1 |
GSTM1 |
Deletion (*) |
52.0% |
0.0% |
48.0% |
N/A |
| Glutathione S-transferase pi |
GSTP1 |
313A>G |
57.8% |
33.3% |
8.9% |
0.68 |
| 341C>T |
56.8% |
34.1% |
9.1% |
1.00 |
||
| Glutathione S-transferase theta 1 |
GSTT1 |
Deletion (*) |
86.0% |
0.0% |
14.0% |
N/A |
| Interleukin 6 |
IL6 |
-174G>C |
66.7% |
33.3% |
0.0% |
0.37 |
| -634G>C |
86.0% |
14.0% |
0.0% |
0.89 |
||
| Lipoprotein lipase |
LPL |
1595C>G |
69.8% |
27.9% |
2.3% |
1.00 |
| 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
MTRR |
66A>G |
19.0% |
45.2% |
35.7% |
0.90 |
| 5,10-methylenetetrahydrofolate reductase |
MTHFR |
1298A>C |
34.0% |
48.9% |
17.0% |
1.00 |
| 677 C>T |
48.0% |
44.0% |
8.0% |
0.95 |
||
| 5-methyltetrahydrofolate-homocysteine methyltransferase |
MTR |
2756A>G |
59.5% |
33.3% |
7.1% |
0.86 |
| Nitric oxide synthase 3 (endothelial cell) |
NOS3 |
894G>T |
44.2% |
44.2% |
11.6% |
1.00 |
| Peroxisome proliferator-activated receptor gamma |
PPARG |
Pro12Ala |
75.6% |
15.6% |
8.9% |
0.02 |
| Superoxide dismutase 2, mitochondrial |
SOD2 |
-28C>T |
10.0% |
54.0% |
36.0% |
0.57 |
| Superoxide dismutase 3, extracellular |
SOD3 |
760C>G |
100.0% |
0.0% |
0.0% |
1.00 |
| Tumor necrosis factor |
TNFα |
-308G>A |
71.1% |
24.4% |
4.4% |
0.72 |
| Vitamin D receptor |
VDR |
C Taq1 T |
23.3% |
46.5% |
30.2% |
0.91 |
| T Bsm1 C |
23.3% |
46.5% |
30.2% |
0.91 |
||
| T Fok1 C |
11.6% |
58.1% |
30.2% |
0.41 |
||
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Genotype frequencies in the study group and p-values for Hardy Weinberg Equilibrium (HWE) are shown. (*) the assay only measured presence or absence of the deletion so a HWE test is not applicable. | ||||||
Arkadianos et al. Nutrition Journal 2007 6:29 doi:10.1186/1475-2891-6-29 |
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