Table 2

Genes and polymorphisms tested in the nutrigenetic patient group.

Gene

Gene symbol

Polymorphism

% homozygote wild type

% heterozygote

% homozygote variant

HWE p <


Angiotensin I converting enzyme

ACE

INS/DEL

14.6%

48.8%

36.6%

0.99

Apolipoprotein C-III

APOC3

3175C>G

73.3%

20.0%

6.7%

0.17

Cystathionine-beta-synthase

CBS

699C>T

53.5%

41.9%

4.7%

0.81

Cholesteryl ester transfer protein

CETP

279G>A

48.8%

39.5%

11.6%

0.86

Collagen, type I, alpha 1

COL1A1

G Sp1 T

58.1%

34.9%

7.0%

0.94

Glutathione S-transferase M1

GSTM1

Deletion (*)

52.0%

0.0%

48.0%

N/A

Glutathione S-transferase pi

GSTP1

313A>G

57.8%

33.3%

8.9%

0.68

341C>T

56.8%

34.1%

9.1%

1.00

Glutathione S-transferase theta 1

GSTT1

Deletion (*)

86.0%

0.0%

14.0%

N/A

Interleukin 6

IL6

-174G>C

66.7%

33.3%

0.0%

0.37

-634G>C

86.0%

14.0%

0.0%

0.89

Lipoprotein lipase

LPL

1595C>G

69.8%

27.9%

2.3%

1.00

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

MTRR

66A>G

19.0%

45.2%

35.7%

0.90

5,10-methylenetetrahydrofolate reductase

MTHFR

1298A>C

34.0%

48.9%

17.0%

1.00

677 C>T

48.0%

44.0%

8.0%

0.95

5-methyltetrahydrofolate-homocysteine methyltransferase

MTR

2756A>G

59.5%

33.3%

7.1%

0.86

Nitric oxide synthase 3 (endothelial cell)

NOS3

894G>T

44.2%

44.2%

11.6%

1.00

Peroxisome proliferator-activated receptor gamma

PPARG

Pro12Ala

75.6%

15.6%

8.9%

0.02

Superoxide dismutase 2, mitochondrial

SOD2

-28C>T

10.0%

54.0%

36.0%

0.57

Superoxide dismutase 3, extracellular

SOD3

760C>G

100.0%

0.0%

0.0%

1.00

Tumor necrosis factor

TNF╬▒

-308G>A

71.1%

24.4%

4.4%

0.72

Vitamin D receptor

VDR

C Taq1 T

23.3%

46.5%

30.2%

0.91

T Bsm1 C

23.3%

46.5%

30.2%

0.91

T Fok1 C

11.6%

58.1%

30.2%

0.41


Genotype frequencies in the study group and p-values for Hardy Weinberg Equilibrium (HWE) are shown. (*) the assay only measured presence or absence of the deletion so a HWE test is not applicable.

Arkadianos et al. Nutrition Journal 2007 6:29   doi:10.1186/1475-2891-6-29

Open Data