Table 3

Associations of BMI, percent body fat, central fat (trunk fat), peripheral fat, and lean mass with serum leptin concentrations

Leptin, ng/mL

Δ (95% C.I.)

P-value

Multiple R2


BMI

Model 1

10.65 (8.16–13.19)

< 0.0001

0.68

Model 2

% Fat

Model 1

7.77 (6.56–8.98)

< 0.0001

0.82

Model 2

7.20 (4.72–9.75)

< 0.0001

0.82

Central fat

Model 1

11.93 (9.72–14.18)

< 0.0001

0.77

Model 2

11.58 (5.87–17.61)

0.0002

0.77

Peripheral fat

Model 1

10.55 (8.33–12.81)

< 0.0001

0.72

Model 2

7.98 (2.13–14.16)

0.01

0.73

Lean mass

Model 1

8.61 (3.76–13.68)

0.001

0.31

Model 2

-0.85 (-4.81–3.25)

0.68

0.68


Δ - Percent change for serum leptin concentration for a one-unit change in each of the adiposity measures (i.e., percent change in leptin concentration per one-unit change in BMI, per 1% increase in total body fat, per 1 kg increase in central and peripheral fat and lean mass).

Model 1: Adjusted for age, race, family history of breast cancer, parity and menarche < 12 years

Model 2: Model 1 + BMI

Mahabir et al. Nutrition Journal 2007 6:3   doi:10.1186/1475-2891-6-3

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