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Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers

Yoram Bouhnik1*, Lotfi Achour2, Damien Paineau3, Michel Riottot4, Alain Attar1 and Francis Bornet3

Author affiliations

1 Pôle des Maladies de l'Appareil Digestif (PMAD), Service de Gastroentérologie et d'Assistance Nutritive, Hôpital Beaujon, 100 bd du Général Leclerc, 92110 Clichy Cedex, France

2 Institut Supérieur de Biotechnologie, avenue Taher El HADED, BP.74, 5000 Monastir, Tunisia

3 Nutri-Health SA, Immeuble Ampère, 8 rue Eugène et Armand Peugeot, 92566 Rueil-Malmaison Cedex, France

4 Université Paris Sud, Laboratoire de Physiologie de la Nutrition, Bat. 447, 91405 ORSAY Cedex, France

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Citation and License

Nutrition Journal 2007, 6:42  doi:10.1186/1475-2891-6-42

Published: 5 December 2007

Abstract

Background

Short-chain fructo-oligosaccharides (scFOS) are increasingly used in human diet for their prebiotic properties. We aimed at investigating the effects of scFOS ingestion on the colonic microflora and oro-fecal transit time in elderly healthy humans.

Methods

Stools composition, oro-fecal transit time, and clinical tolerance were evaluated in 12 healthy volunteers, aged 69 ± 2 yrs, in three consecutive periods: basal period (2 weeks), scFOS (Actilight®) ingestion period (8 g/d for 4 weeks) and follow-up period (4 weeks). Two-way ANOVA, with time and treatment as factors, was used to compare the main outcome measures between the three periods.

Results

Fecal bifidobacteria counts were significantly increased during the scFOS period (9.17 ± 0.17 log cfu/g vs 8.52 ± 0.26 log cfu/g during the basal period) and returned to their initial values at the end of follow-up (8.37 ± 0.21 log cfu/g; P < 0.05). Fecal cholesterol concentration increased during the scFOS period (8.18 ± 2.37 mg/g dry matter vs 2.81 ± 0.94 mg/g dry matter during the basal period) and returned to the baseline value at the end of follow-up (2.87 ± 0.44 mg/g dry matter; P < 0.05). Fecal pH tended to decrease during scFOS ingestion and follow-up periods compared to the basal period (P = 0.06). Fecal bile acids, stool weight, water percentage, and oro-fecal transit time did not change throughout the study. Excess flatus and bloating were significantly more frequent during scFOS ingestion when compared to the basal period (P < 0.05), but the intensity of these symptoms was very mild.

Conclusion

Four-week 8 g/d scFOS ingestion is well tolerated and leads to a significant increase in fecal bifidobacteria in healthy elderly subjects. Whether the change in cholesterol metabolism found in our study could exert a beneficial action warrants further studies.