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Open Access Highly Accessed Review

The underlying mechanisms for development of hypertension in the metabolic syndrome

Hidekatsu Yanai1*, Yoshiharu Tomono1, Kumie Ito1, Nobuyuki Furutani1, Hiroshi Yoshida2 and Norio Tada1

Author Affiliations

1 Department of Internal Medicine, The Jikei University School of Medicine, Chiba, Japan

2 Department of Laboratory Medicine, The Jikei University School of Medicine, Chiba, Japan

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Nutrition Journal 2008, 7:10  doi:10.1186/1475-2891-7-10

Published: 17 April 2008

Abstract

High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.