Table 2 |
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|
Mean change from baseline in serum biomarkers during feeding study – Average American vs. Intervention Diet1 |
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| Baseline |
Change Following Average American Diet2 |
Change Following Intervention Diet2 |
P-value for Difference in Change |
|
|
|
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| Total cholesterol, mmol/L |
5.01 ± 0.16 |
-0.02 ± 0.12 |
-0.18 ± 0.12 |
0.13 |
| HDL, mmol/L |
1.36 ± 0.06 |
-0.04 ± 0.04 |
-0.05 ± 0.04 |
0.95 |
| Oxidized LDL, mmol/L |
2.61 ± 0.16 |
-0.15 ± 0.11 |
-0.16 ± 0.11 |
0.98 |
| Triglycerides3, mmol/L |
1.31 ± 1.01 |
1.00 ± 1.00 |
1.00 ± 1.00 |
0.48 |
| LDL, mmol/L |
3.11 ± 0.15 |
0.03 ± 0.13 |
-0.10 ± 0.13 |
0.21 |
| LDL:HDL |
2.37 ± 0.16 |
0.15 ± 0.15 |
0.04 ± 0.15 |
0.34 |
| Non-HDL:HDL |
2.79 ± 0.19 |
0.18 ± 0.15 |
0.03 ± 0.15 |
0.28 |
| Total PSA, μg/L |
5.02 ± 0.63 |
-0.07 ± 0.35 |
0.05 ± 0.36 |
0.75 |
| Free PSA, μg/L |
0.92 ± 0.13 |
0.05 ± 0.10 |
0.13 ± 0.10 |
0.56 |
| Percent Free PSA3, % |
38.8 ± 1.04 |
1.03 ± 1.03 |
0.99 ± 1.03 |
0.07 |
| Testosterone nmol/L |
16.4 ± 1.11 |
-0.60 ± 0.70 |
-0.75 ± 0.70 |
0.82 |
| Bioavailable testosterone nmol/L |
4.66 ± 0.29 |
-0.35 ± 0.26 |
-0.34 ± 0.26 |
0.99 |
| Percent bioavailable testosterone, % |
0.92 ± 0.13 |
-0.85 ± 0.93 |
-0.45 ± 0.94 |
0.66 |
| IGF-1, μg/L |
143 ± 9.11 |
10.6 ± 5.85 |
1.79 ± 6.07 |
0.13 |
| 3α-Androstanediol glucuronide, nmol/L |
13.8 ± 1.55 |
-0.02 ± 0.01 |
-0.02 ± 0.01 |
0.90 |
| Estradiol, pmol/L |
97.7 ± 5.74 |
1.22 ± 4.02 |
-3.85 ± 4.02 |
0.34 |
| Alpha-tocopherol,4 μmol/L |
29.3 ± 2.19 |
-0.71 ± 1.30 |
-2.65 ± 1.30 |
0.13 |
| Gamma- tocopherol,4 μmol/L |
4.14 ± 0.43 |
0.26 ± 0.52 |
0.83 ± 0.52 |
0.08 |
| Tocopherol ratio alpha:gamma4 |
11.0 ± 9.91 |
-0.51 ± 1.99 |
-3.49 ± 1.99 |
0.01 |
|
|
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|
1Values are least-squares means ± SEM, n = 21. Data presented from the final model, in which weight was significant only for tocopherols and IGF-1 and was omitted for all other variables. 2Change scores calculated for each diet as Δ = mean concentration following diet – mean concentration at baseline. 3Triglyceride and percent free PSA (n = 20) change score data were log-transformed, and change scores are presented as geometric means. 4 n = 20. Tocopherol change score adjusted for change in weight between the two diets. |
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|
Spaccarotella et al. Nutrition Journal 2008 7:13 doi:10.1186/1475-2891-7-13 |
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