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Comparison of enteral nutrition with combined enteral and parenteral nutrition in post-pancreaticoduodenectomy patients: a pilot study

Shigeyuki Nagata12*, Kengo Fukuzawa2, Yukio Iwashita2, Akira Kabashima2, Tadahiko Kinoshita2, Kenzo Wakasugi2 and Yoshihiko Maehara1

Author affiliations

1 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

2 Department of Surgery, Oita Red Cross Hospital, Oita, Japan

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Citation and License

Nutrition Journal 2009, 8:24  doi:10.1186/1475-2891-8-24

Published: 11 June 2009



Many clinical studies have demonstrated that early postoperative enteral nutrition (EN) improved the postroperative course. Post-pancreaticoduodenectomy (PD), patients tend to suffer from postoperative nausea, abdominal distention, and diarrhoea, causing difficulty in the introduction of EN. In this pilot study, we investigated the appropriate nutritional mode post-pancreatic surgery.


Between October 2006 and March 2007 2 postoperative nutritional methods were implemented in 17 patients in a prospective single-centere study. Eight patients received only enteral nutrition (EN group) and 9 patients received enteral nutrition combined with parenteral nutrition (EN + PN group).


There were no differences in the patient characteristics and postoperative morbidity between the 2 groups. The rate of discontinuance of enteral feeding was significantly high in the EN group, and the duration of enteral feeding was significantly longer in the EN + PN group. The central venous line was retained for a significantly longer period in the EN + PN group, but there was no difference in the frequency of catheter-related infection between the 2 groups.


EN combined with PN is more adequate for patients after pancreatic surgery.