Table 1

Changes in parameters before and after 2-week once daily oral administration of octanoic acid formula to cachectic patients with chronic respiratory disease.

Before

After


body mass index

(kg/m2)

16.0 ± 2.00

16.3 ± 2.00

p < 0.05

appetite score

40 ± 22

64 ± 27

p < 0.05

acyl-ghrelin

(fmol/ml)

11.0 ± 11.1

14.8 ± 7.20

p < 0.05

desacyl-ghrelin

(fmol/ml)

90.1 ± 52.4

90.9 ± 52.5

NS

total protein

(g/dl)

6.9 ± 0.6

7.3 ± 0.7

p < 0.05

albumin

(g/dl)

3.8 ± 0.4

4.0 ± 0.4

p < 0.05

total cholesterol

(mg/dl)

181 ± 40

184 ± 210

NS

fasting glucose

(mg/dl)

94 ± 9

91 ± 90

NS

prealbumin

(mg/dl)

15.8 ± 4.20

17.9 ± 3.90

p < 0.05

transferrin

(mg/dl)

198 ± 41

231 ± 570

p < 0.05

retinol binding protein

(mg/dl)

1.9 ± 0.4

2.3 ± 0.5

p < 0.05

adrenalin

(pg/ml)

63 ± 40

60 ± 21

NS

noradrenalin

(pg/ml)

852 ± 320

724 ± 298

NS

dopamine

(pg/ml)

24 ± 10

18 ± 60

NS

GH

(ng/ml)

1.2 ± 1.0

1.3 ± 1.1

NS

IGF-1

(ng/ml)

87 ± 36

98 ± 39

p < 0.05


Age: range 62–78 y; sex:8 women, 11 men; oral 400 ml octanoic acid formula administered once daily after breakfast in addition to food intake of 1,800 kcal

Ashitani et al. Nutrition Journal 2009 8:25   doi:10.1186/1475-2891-8-25

Open Data