Alexander Semmler, Susanna Moskau, Andreas Grigull, Susan Farmand, Thomas Klockgether, Yvo Smulders, Henk Blom, Bernd Zur, Birgit Stoffel-Wagner and Michael Linnebank*
Corresponding author: Michael Linnebank firstname.lastname@example.org
Nutrition Journal 2010, 9:31 doi:10.1186/1475-2891-9-31
(2012-01-06 14:39) Tehran University of Medical Sciences
Title of commentary:
Another aspect of the difference between high folate and vitamin B12 intake on lipid
Commentary letter about article:
��Plasma folate levels are associated with the lipoprotein profile a retrospective
database analysis: Semmler et al: Nutrition Journal. 2010; 9: 31��
Commentary by: Roya Kolahdouz Mohammadi (MSc in Nutrition Sciences), Assistant Professor
Ahmad Saedisomeolia (PhD in Nutrition Sciences)
Department of Nutrition and Biochemistry, School of Public Health, Tehran University
of Medical Sciences, Tehran, Iran
In this paper, it has been shown that: high folate levels are associated with increased
levels of HDL, lower levels of LDL and a lower LDL/HDL ratio. However, vitamin B12
is not associated with the lipoprotein profile. The explanation of the authors about
the possible reasons for the positive relationship between folate levels and favorable
lipid profile is supposed to be incomplete. This commentary letter encourages the
readers of this paper to think about one of the most possible explanations of this
However, folate and vitamin B12 serve as single-carbon transporters (and play a key
role in inhibition of homocystein production which is supported by the authors of
the article), there is a fundamental difference between folate and vitamin B12. Folate
is provided mostly from plant foods, however, the most significant natural dietary
source of vitamin B12 is animal foods. Therefore, we believe that high folate level
is resulted from a healthy diet (including: high plant food, high dietary fiber intake,
less saturated fat and low calorie diet) . On the other hand, high vitamin B12
levels are expected to be related to high animal food sources [reviewed in  which
may affect inversely on favorable lipid profile. Therefore, it is suggested to the
readers of this paper to consider the other aspect of the difference between high
folate and vitamin B12 group studied in this paper. We conclude that the difference
between the nutritional patterns of the participants (whether they are consuming plant
or animal foods) can affect their lipid profile.
1. De Biase, S.G., et al., Vegetarian diet and cholesterol and triglycerides levels.
Arq Bras Cardiol, 2007. 88(1): p. 35-9.
2. Watanabe, F., Vitamin B12 sources and bioavailability. Exp Biol Med (Maywood),
2007. 232(10): p. 1266-74.
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